WWTR1

WWTR1
Identifiers
Aliases	WWTR1, TAZ, WW domain containing transcription regulator 1
External IDs	OMIM: 607392 MGI: 1917649 HomoloGene: 9159 GeneCards: WWTR1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	149,736,714 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	57,483,331 bp
RNA expression pattern
	Top expressed in
	tibia; ; optic nerve; ; visceral pleura; ; seminal vesicula; ; urethra; ; saphenous vein; ; lower lobe of lung; ; vena cava; ; periodontal fiber; ; parietal pleura;
	Top expressed in
	left lung lobe; ; right lung lobe; ; atrioventricular valve; ; dermis; ; saccule; ; semi-lunar valve; ; body of femur; ; atrium; ; sciatic nerve; ; vas deferens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; transcription corepressor activity; transcription coactivator activity; protein binding;
Cellular component	cytoplasm; transcription regulator complex; nucleoplasm; nucleus; cytosol; nuclear body;
Biological process	negative regulation of protein phosphorylation; cilium assembly; regulation of metanephric nephron tubule epithelial cell differentiation; negative regulation of fat cell differentiation; regulation of transcription, DNA-templated; negative regulation of protein kinase activity; multicellular organism growth; regulation of canonical Wnt signaling pathway; glomerulus development; negative regulation of transcription by RNA polymerase II; hippo signaling; positive regulation of epithelial to mesenchymal transition; regulation of SMAD protein signal transduction; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; mesenchymal cell differentiation; stem cell division; protein ubiquitination; osteoblast differentiation; kidney morphogenesis; positive regulation of cell population proliferation; transcription initiation from RNA polymerase II promoter; negative regulation of canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; tissue homeostasis; heart process;
	Sources:Amigo / QuickGO
Orthologs
	25937
	97064
	ENSG00000018408
	ENSMUSG00000027803
	Q9GZV5
	Q9EPK5
	NM_001168278; NM_001168280; NM_015472; NM_001348362
	NM_001168281; NM_133784
	NP_001161750; NP_001161752; NP_056287; NP_001335291
	NP_001161753; NP_598545
	Wikidata
View/Edit Human	View/Edit Mouse

WW domain-containing transcription regulator protein 1 (WWTR1), also known as Transcriptional coactivator with PDZ-binding motif (TAZ), is a protein that in humans is encoded by the WWTR1 gene. WWTR1 acts as a transcriptional coregulator and has no effect on transcription alone. When in complex with transcription factor binding partners, WWTR1 helps promote gene expression in pathways associated with development, cell growth and survival, and inhibiting apoptosis. Aberrant WWTR1 function has been implicated for its role in driving cancers. WWTR1 is often referred to as TAZ due to its initial characterization with the name TAZ. However, WWTR1 (TAZ) is not to be confused with the protein tafazzin, which originally held the official gene symbol TAZ, and is now TAFAZZIN.

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