Wilms tumor protein

WT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XF7, 2JP9, 2JPA, 2PRT, 3HPJ, 3MYJ, 4R2E, 4R2P, 4R2Q, 4R2R, 4R2S, 4WUU
Identifiers
Aliases	WT1, AEWS-GUD, NPHS4, WAGR, WIT-2, WT33, Wilms tumor 1, WT1 transcription factor, WT-1
External IDs	OMIM: 607102 MGI: 98968 HomoloGene: 11536 GeneCards: WT1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	32,435,564 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	105,003,961 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; glomerulus; ; metanephric glomerulus; ; parietal pleura; ; right uterine tube; ; left uterine tube; ; myometrium; ; endometrium; ; pericardium; ; peritoneum;
	Top expressed in
	dorsal mesentery; ; germinal epithelium; ; coelomic epithelium; ; vas deferens; ; ovarian follicle; ; uterus; ; squamous epithelium; ; mesothelium; ; atrium; ; endocardial cushion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; C2H2 zinc finger domain binding; metal ion binding; protein binding; RNA binding; nucleic acid binding; double-stranded methylated DNA binding; hemi-methylated DNA-binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nuclear speck; nucleoplasm; nucleolus; nucleus; cytosol;
Biological process	germ cell development; adrenal cortex formation; ureteric bud development; negative regulation of translation; male gonad development; male genitalia development; regulation of transcription, DNA-templated; epithelial cell differentiation; glomerular basement membrane development; diaphragm development; kidney development; regulation of transcription by RNA polymerase II; posterior mesonephric tubule development; visceral serous pericardium development; metanephric epithelium development; negative regulation of apoptotic process; glomerulus development; negative regulation of transcription by RNA polymerase II; adrenal gland development; transcription, DNA-templated; positive regulation of metanephric ureteric bud development; vasculogenesis; positive regulation of transcription, DNA-templated; positive regulation of heart growth; heart development; negative regulation of female gonad development; branching involved in ureteric bud morphogenesis; regulation of animal organ formation; sex-determination system; negative regulation of cell growth; RNA splicing; cardiac muscle cell fate commitment; tissue development; positive regulation of apoptotic process; camera-type eye development; metanephric S-shaped body morphogenesis; thorax and anterior abdomen determination; negative regulation of transcription, DNA-templated; gonad development; metanephric mesenchyme development; cellular response to gonadotropin stimulus; positive regulation of male gonad development; cellular response to cAMP; negative regulation of cell population proliferation; mesenchymal to epithelial transition; negative regulation of metanephric glomerular mesangial cell proliferation; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; glomerular visceral epithelial cell differentiation; positive regulation of gene expression; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of DNA methylation;
	Sources:Amigo / QuickGO
Orthologs
	7490
	22431
	ENSG00000184937
	ENSMUSG00000016458
	P19544
	P22561; Q199A7
NM_024426; NM_000378; NM_001198551; NM_001198552; NM_024424;
	NM_024425; NM_001367854
	NM_144783
NP_000369; NP_001185480; NP_001185481; NP_077742; NP_077744;
	NP_001354783; NP_000369.3; NP_001185480.1; NP_001185481.1; NP_077742.2; NP_077744.3
	NP_659032
	Wikidata
View/Edit Human	View/Edit Mouse

Wilms tumor protein (WT33) is a protein that in humans is encoded by the WT1 gene on chromosome 11p.

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