WS-12

WS-12
Names
	Preferred IUPAC name (1R,2S,5R)-N-(4-Methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide
Identifiers
CAS Number	68489-09-8;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL2441929;
ChemSpider	9441255;
EC Number	700-232-9;
PubChem CID	11266244;
UNII	1L7BVT4Z4Z;
CompTox Dashboard (EPA)	DTXSID10460636 ;
	InChI InChI=1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16+,17-/m1/s1 Key: HNSGVPAAXJJOPQ-XOKHGSTOSA-N;
	SMILES C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C;
Properties
Chemical formula	C18H27NO2
Molar mass	289.419 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

WS-12 is a chemical compound that acts as a potent and selective activator of the TRPM8 calcium channel, which is responsible for the sensation of coldness produced by menthol. It is slightly less potent as a TRPM8 activator compared to icilin, but is much more selective for TRPM8 over related calcium channels. It produces analgesic and antiinflammatory effects in animal models with similar efficacy to menthol and a reduced side effect profile.

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