Viperin
Radical S-adenosyl methionine domain-containing protein 2 is a protein that in humans is encoded by the RSAD2 gene. RSAD2 is a multifunctional protein in viral processes that is an interferon stimulated gene. It has been reported that viperin could be induced by either IFN-dependent or IFN-independent pathways and certain viruses may use viperin to increase their infectivity.
The protein was previous called Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible (Viperin). The name viperin has been rectified due to inappropriate use of it to describe homologous prokaryotic enzymes producing nucleotide analogues. The enzymes across all domains of life are renamed SAM-dependent nucleotide dehydratase (SAND) using NC-IUBMB recommendations.