Viperin

Radical S-adenosyl methionine domain-containing protein 2 is a protein that in humans is encoded by the RSAD2 gene. RSAD2 is a multifunctional protein in viral processes that is an interferon stimulated gene. It has been reported that viperin could be induced by either IFN-dependent or IFN-independent pathways and certain viruses may use viperin to increase their infectivity.

RSAD2
Identifiers
AliasesRSAD2, 2510004L01Rik, cig33, cig5, vig1, radical S-adenosyl methionine domain containing 2, Viperin Protein, Viperin
External IDsOMIM: 607810 MGI: 1929628 HomoloGene: 10969 GeneCards: RSAD2
Orthologs
SpeciesHumanMouse
Entrez

91543

58185

Ensembl

ENSG00000134321

ENSMUSG00000020641

UniProt

Q8WXG1

Q8CBB9

RefSeq (mRNA)

NM_080657

NM_021384

RefSeq (protein)

NP_542388

NP_067359

Location (UCSC)Chr 2: 6.87 – 6.9 MbChr 12: 26.49 – 26.51 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

The protein was previous called Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible (Viperin). The name viperin has been rectified due to inappropriate use of it to describe homologous prokaryotic enzymes producing nucleotide analogues. The enzymes across all domains of life are renamed SAM-dependent nucleotide dehydratase (SAND) using NC-IUBMB recommendations.

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