Vinculin

VCL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RKC, 1RKE, 1SYQ, 1TR2, 2GWW, 2IBF, 3H2U, 3H2V, 3MYI, 3TJ5, 3TJ6, 3VF0, 4DJ9, 4EHP, 1YDI, 2HSQ, 3RF3, 3S90, 4LN2, 4LNP, 4PR9, 3JBK
Identifiers
Aliases	VCL, CMD1W, CMH15, HEL114, MV, Mvinculin
External IDs	OMIM: 193065 MGI: 98927 HomoloGene: 7594 GeneCards: VCL
Gene location (Human)
Chr.	Chromosome 10 (human)
End	74,121,363 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	21,083,744 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; urethra; ; vena cava; ; smooth muscle tissue; ; right coronary artery; ; popliteal artery; ; nipple; ; seminal vesicula; ; myometrium; ; ascending aorta;
	Top expressed in
	calvaria; ; belly cord; ; ascending aorta; ; right lung; ; left lung; ; carotid body; ; left lung lobe; ; semi-lunar valve; ; right lung lobe; ; atrioventricular valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	beta-catenin binding; dystroglycan binding; structural molecule activity; protein binding; actin binding; alpha-catenin binding; ubiquitin protein ligase binding; cadherin binding;
Cellular component	cytoplasm; extracellular vesicle; cytosol; outer dense plaque of desmosome; membrane; cell-cell junction; focal adhesion; cell-substrate junction; adherens junction; plasma membrane; inner dense plaque of desmosome; terminal web; extracellular region; cell junction; brush border; actin cytoskeleton; zonula adherens; membrane raft; fascia adherens; costamere; cytoskeleton; extracellular exosome; podosome; secretory granule lumen; specific granule lumen; ficolin-1-rich granule lumen; sarcolemma;
Biological process	regulation of cell migration; muscle contraction; adherens junction assembly; epithelial cell-cell adhesion; platelet degranulation; morphogenesis of an epithelium; cell adhesion; negative regulation of cell migration; protein localization to cell surface; axon extension; cell-matrix adhesion; platelet aggregation; apical junction assembly; lamellipodium assembly; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	7414
	22330
	ENSG00000035403
	ENSMUSG00000021823
	P18206
	Q64727
	NM_003373; NM_014000
	NM_009502
	NP_003364; NP_054706
	NP_033528
	Wikidata
View/Edit Human	View/Edit Mouse

In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane.

Discovered independently by Benny Geiger and Keith Burridge, its sequence is 20%–30% similar to α-catenin, which serves a similar function.

Binding alternately to talin or α-actinin, vinculin's shape and, as a consequence, its binding properties are changed. The vinculin gene occurs as a single copy and what appears to be no close relative to take over functions in its absence. Its splice variant metavinculin (see below) also needs vinculin to heterodimerize and work in a dependent fashion.

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