Hydrocodone/paracetamol

Hydrocodone/paracetamol
Combination of
Hydrocodone	Opioid analgesic
Paracetamol	Anilide analgesic
Clinical data
Trade names	Lorcet, Norco, Vicodin, others
Other names	Hydrocodone/acetaminophen, hydrocodone/APAP
AHFS/Drugs.com	Professional Drug Facts
License data	US DailyMed: Hydrocodone bitartrate and acetaminophen;
Routes of; administration	By mouth
ATC code	N02AJ22 (WHO) ;
Legal status
Legal status	US: Schedule II;
Pharmacokinetic data
Bioavailability	>80%
Metabolism	Hydrocodone: extensively liver, primarily CYP3A4;; /Paracetamol: liver, CYP2E1
Elimination half-life	for hydrocodone: 228–294 mins (3.8–4.9 hrs); for paracetamol: 120–240 mins (2–4 hrs)
Excretion	for hydrocodone: urinary; for paracetamol: urinary (10–15% unchanged)
Identifiers
CAS Number	330988-71-1 ;
PubChem CID	11247932;
ChemSpider	9422965 ;
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Hydrocodone/paracetamol (also known as hydrocodone/acetaminophen) is the combination of the pain medications hydrocodone and paracetamol (acetaminophen). It is used to treat moderate to severe pain. It is taken by mouth. Recreational use is common in the United States.

Common side effects include dizziness, sleepiness, constipation, and vomiting. Serious side effects include addiction, decreased rate of breathing, low blood pressure, serotonin syndrome, severe allergic reactions, and liver failure. Use during pregnancy may harm the fetus. Use with alcohol is not recommended. Hydrocodone works by binding to the mu-opioid receptor. How paracetamol works is unclear but may involve blocking the creation of prostaglandins.

Hydrocodone/paracetamol was approved for medical use in the United States in 1982. In the United States, it is a schedule II controlled substance. In 2021, it was the twentieth most commonly prescribed medication in the United States, with more than 26 million prescriptions. It is not available in the United Kingdom, though the combination codeine/paracetamol (co-codamol) is. It is sold under the brand names Vicodin and Norco among others.

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