Vasopressin receptor 2

AVPR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JQI
Identifiers
Aliases	AVPR2, ADHR, DI1, DIR, DIR3, NDI, V2R, arginine vasopressin receptor 2, NDI1
External IDs	OMIM: 300538 MGI: 88123 HomoloGene: 20064 GeneCards: AVPR2
Gene location (Human)
Chr.	X chromosome (human)
End	153,907,166 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	72,939,108 bp
RNA expression pattern
	Top expressed in
	subcutaneous adipose tissue; ; left ventricle; ; vena cava; ; kidney; ; left uterine tube; ; gastrocnemius muscle; ; skeletal muscle tissue; ; gastric mucosa; ; tibial nerve; ; myometrium;
	Top expressed in
	kidney; ; medullary collecting duct; ; thymus; ; primary motor cortex; ; meninges; ; spleen; ; bone marrow; ; superior colliculus; ; retina; ; dentate gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; peptide binding; signal transducer activity; protein binding; vasopressin receptor activity;
Cellular component	integral component of membrane; endosome; Golgi apparatus; membrane; plasma membrane; integral component of plasma membrane; endoplasmic reticulum; clathrin-coated vesicle membrane;
Biological process	hemostasis; excretion; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; regulation of systemic arterial blood pressure by vasopressin; activation of adenylate cyclase activity; response to peptide; cellular response to hormone stimulus; positive regulation of vasoconstriction; renal water homeostasis; positive regulation of protein ubiquitination; signal transduction; membrane organization; G protein-coupled receptor signaling pathway; positive regulation of gene expression; positive regulation of systemic arterial blood pressure; I-kappaB kinase/NF-kappaB signaling; positive regulation of cell population proliferation; telencephalon development; response to cytokine; negative regulation of urine volume; negative regulation of renal sodium excretion; positive regulation of blood pressure;
	Sources:Amigo / QuickGO
Orthologs
	554
	12000
	ENSG00000126895
	ENSMUSG00000031390
	P30518
	O88721
	NM_000054; NM_001146151
	NM_001276298; NM_001276299; NM_019404
	NP_000045; NP_001139623
	NP_001263227; NP_001263228; NP_062277
	Wikidata
View/Edit Human	View/Edit Mouse

Vasopressin receptor 2 (V2R), or arginine vasopressin receptor 2 (officially called AVPR2), is a protein that acts as receptor for vasopressin. AVPR2 belongs to the subfamily of G-protein-coupled receptors. Its activity is mediated by the G_s type of G proteins, which stimulate adenylate cyclase.

AVPR2 is expressed in the kidney tubule, predominantly in the membrane of cells of the distal convoluted tubule and collecting ducts, in fetal lung tissue and lung cancer, the last two being associated with alternative splicing. AVPR2 is also expressed outside the kidney in vascular endothelium. Stimulation causes the release of von Willebrand factor and factor VIII from the endothelial cells. Because von Willebrand factor helps stabilize circulating levels of factor VIII, the vasopressin analog desmopressin can be used to stimulate the AVPR2 receptor and increase levels of circulating factor VIII. This is useful in the treatment of hemophilia A as well as Von Willebrand disease.

In the kidney, AVPR2's primary property is to respond to arginine vasopressin by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of AVPR2 is lost, the disease nephrogenic diabetes insipidus (NDI) results.

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