Valganciclovir

Valganciclovir
Clinical data
Trade names	Valcyte, Valcip, others
AHFS/Drugs.com	Monograph
MedlinePlus	a605021
License data	US DailyMed: Valganciclovir;
Pregnancy; category	AU: D;
Routes of; administration	By mouth
ATC code	J05AB14 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	60%
Protein binding	1–2%
Metabolism	Hydrolysed to ganciclovir
Elimination half-life	4 hours
Excretion	Kidney
Identifiers
	IUPAC name 2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]-3-hydroxypropyl-(2S)-2-amino-3-methylbutanoate;
CAS Number	175865-60-8 ;
PubChem CID	135413535;
IUPHAR/BPS	4716;
DrugBank	DB01610 ;
ChemSpider	57721 ;
UNII	GCU97FKN3R;
KEGG	D02495; as HCl: D03256;
ChEMBL	ChEMBL1201314 ;
NIAID ChemDB	032967;
PDB ligand	F9E (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID8048288 ;
Chemical and physical data
Formula	C14H22N6O5
Molar mass	354.367 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC(OCn1c2N\C(=N/C(=O)c2nc1)N)CO)[C@@H](N)C(C)C;
	InChI InChI=1S/C14H22N6O5/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22)/t8?,9-/m0/s1 ; Key:WPVFJKSGQUFQAP-GKAPJAKFSA-N ;
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Valganciclovir, sold under the brand name Valcyte among others, is an antiviral medication used to treat cytomegalovirus (CMV) infection in those with HIV/AIDS or following organ transplant. It is often used long term as it only suppresses rather than cures the infection. Valganciclovir is taken by mouth.

Common side effects include abdominal pain, headaches, trouble sleeping, nausea, fever, and low blood cell counts. Other side effects may include infertility and kidney problems. When used during pregnancy, it causes birth defects in some animals. Valganciclovir is the L-valyl ester of ganciclovir and works when broken down into ganciclovir by the intestine and liver.

Valganciclovir was approved for medical use in 2001. It is on the World Health Organization's List of Essential Medicines. In 2017, a generic version was approved.

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