Vesicular monoamine transporter 1

SLC18A1
Identifiers
Aliases	SLC18A1, CGAT, VAT1, VMAT1, Vesicular monoamine transporter 1, solute carrier family 18 member A1, VMAT2
External IDs	OMIM: 193002 MGI: 106684 HomoloGene: 20664 GeneCards: SLC18A1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	20,183,206 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	69,541,887 bp
RNA expression pattern
	Top expressed in
	rectum; ; monocyte; ; right adrenal gland; ; appendix; ; substantia nigra; ; duodenum; ; left adrenal gland; ; lymph node; ; body of stomach; ; spleen;
	Top expressed in
	proximal convoluted tubule; ; interventricular septum; ; kidney; ; proximal straight tubule; ; adrenal gland; ; stellate ganglion; ; yolk sac; ; ileum; ; distal tubule; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	monoamine transmembrane transporter activity; xenobiotic transmembrane transporter activity; serotonin:sodium symporter activity;
Cellular component	integral component of membrane; clathrin-sculpted monoamine transport vesicle membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; cytoplasmic vesicle membrane; cytoplasmic vesicle; integral component of plasma membrane; cell junction; synaptic vesicle membrane; synapse; terminal bouton;
Biological process	xenobiotic transmembrane transport; monoamine transport; neurotransmitter transport; aminergic neurotransmitter loading into synaptic vesicle; serotonin transport; transmembrane transport; serotonin uptake; xenobiotic transport;
	Sources:Amigo / QuickGO
Orthologs
	6570
	110877
	ENSG00000036565
	ENSMUSG00000036330
	P54219
	Q8R090
	NM_001135691; NM_001142324; NM_001142325; NM_003053
	NM_153054
	NP_001129163; NP_001135796; NP_001135797; NP_003044
	NP_694694
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicular monoamine transporter 1 (VMAT1) also known as chromaffin granule amine transporter (CGAT) or solute carrier family 18 member 1 (SLC18A1) is a protein that in humans is encoded by the SLC18A1 gene. VMAT1 is an integral membrane protein, which is embedded in synaptic vesicles and serves to transfer monoamines, such as norepinephrine, epinephrine, dopamine, and serotonin, between the cytosol and synaptic vesicles. SLC18A1 is an isoform of the vesicular monoamine transporter.

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