Uromodulin

UMOD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WRN
Identifiers
Aliases	UMOD, ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP, uromodulin, ADTKD1
External IDs	OMIM: 191845 MGI: 102674 HomoloGene: 2522 GeneCards: UMOD
Gene location (Human)
Chr.	Chromosome 16 (human)
End	20,356,301 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	119,078,505 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; kidney; ; kidney tubule; ; metanephric glomerulus; ; body of pancreas; ; urethra; ; gallbladder; ; bone marrow cells; ; body of stomach; ; fundus;
	Top expressed in
	kidney; ; distal tubule; ; Ascending limb of loop of Henle; ; thick ascending limb of loop of Henle; ; thin ascending limb of loop of Henle; ; distal convoluted tubule; ; proximal tubule; ; superior frontal gyrus; ; sexually immature organism; ; cortical collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; IgG binding;
Cellular component	cell projection; spindle pole; membrane; plasma membrane; extracellular region; basolateral plasma membrane; apical plasma membrane; ciliary membrane; anchored component of membrane; extracellular exosome; extrinsic component of membrane; Golgi lumen; cilium;
Biological process	leukocyte cell-cell adhesion; chemical homeostasis; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; excretion; metanephric distal convoluted tubule development; metanephric ascending thin limb development; cellular defense response; neutrophil migration; metanephric thick ascending limb development; negative regulation of cell population proliferation; protein N-linked glycosylation via asparagine; ion homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	7369
	22242
	ENSG00000169344
	ENSMUSG00000030963
	P07911
	Q91X17
NM_001008389; NM_001278614; NM_003361; NM_001378232; NM_001378233;
	NM_001378234; NM_001378235; NM_001378237
	NM_001278605; NM_009470
NP_001008390; NP_001265543; NP_003352; NP_001365161; NP_001365162;
	NP_001365163; NP_001365164; NP_001365166
	NP_001265534; NP_033496
	Wikidata
View/Edit Human	View/Edit Mouse

Uromodulin (UMOD), also known as Tamm–Horsfall protein (THP), is a zona pellucida-like domain-containing glycoprotein that in humans is encoded by the UMOD gene. Uromodulin is the most abundant protein excreted in ordinary urine.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.