Urokinase receptor

PLAUR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YWH, 2FD6, 3BT1, 3BT2, 3U73, 3U74, 2I9B, 4K24, 4QTI
Identifiers
Aliases	PLAUR, CD87, U-PAR, UPAR, URKR, plasminogen activator, urokinase receptor
External IDs	OMIM: 173391 MGI: 97612 HomoloGene: 48120 GeneCards: PLAUR
Gene location (Human)
Chr.	Chromosome 19 (human)
End	43,670,547 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,175,393 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; monocyte; ; stromal cell of endometrium; ; vena cava; ; gallbladder; ; blood; ; bone marrow cells; ; right lung; ; upper lobe of left lung; ; pancreatic ductal cell;
	Top expressed in
	right lung lobe; ; bone marrow; ; calvaria; ; mucous cell of stomach; ; spleen; ; left lung lobe; ; belly cord; ; morula; ; blood; ; endocardial cushion;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; protein binding; urokinase plasminogen activator receptor activity; enzyme binding; signaling receptor binding; signaling receptor activity;
Cellular component	integral component of membrane; cell projection; endoplasmic reticulum lumen; endoplasmic reticulum membrane; membrane; focal adhesion; integral component of plasma membrane; extracellular region; cell junction; anchored component of membrane; extracellular exosome; extrinsic component of membrane; plasma membrane; specific granule membrane; cell surface;
Biological process	positive regulation of protein phosphorylation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; fibrinolysis; negative regulation of intrinsic apoptotic signaling pathway; urokinase plasminogen activator signaling pathway; negative regulation of apoptotic process; blood coagulation; attachment of GPI anchor to protein; chemotaxis; positive regulation of release of cytochrome c from mitochondria; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor signaling pathway; regulation of proteolysis; signal transduction; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	5329
	18793
	ENSG00000011422
	ENSMUSG00000046223
	Q03405
	P35456
	NM_001005376; NM_001005377; NM_001301037; NM_002659
	NM_011113
	NP_001005376; NP_001005377; NP_001287966; NP_002650
	NP_035243
	Wikidata
View/Edit Human	View/Edit Mouse

The Urokinase receptor, also known as urokinase plasminogen activator surface receptor (uPAR) or CD87 (Cluster of Differentiation 87), is a protein encoded in humans by the PLAUR gene. It is a multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. uPAR was originally identified as a saturable binding site for urokinase (also known as uPA) on the cell surface.

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