Netrin receptor DCC

DCC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ED7, 2ED8, 2ED9, 2EDB, 2EDD, 2EDE, 3AU4, 4URT
Identifiers
Aliases	DCC, DCC netrin 1 receptor, CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1, HGPPS2
External IDs	OMIM: 120470 MGI: 94869 HomoloGene: 21081 GeneCards: DCC
Gene location (Human)
Chr.	Chromosome 18 (human)
End	53,535,903 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	72,484,140 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; prefrontal cortex; ; Brodmann area 23; ; nucleus accumbens; ; caudate nucleus; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; sural nerve; ; putamen; ; hippocampus proper;
	Top expressed in
	ganglionic eminence; ; medial ganglionic eminence; ; ventral tegmental area; ; nucleus accumbens; ; pineal gland; ; olfactory tubercle; ; substantia nigra; ; mammillary body; ; lateral hypothalamus; ; supraoptic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; netrin receptor activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; cytosol; membrane; plasma membrane; axon; Schaffer collateral - CA1 synapse; integral component of postsynaptic density membrane;
Biological process	dorsal/ventral axon guidance; negative regulation of neuron projection development; axonogenesis; netrin-activated signaling pathway; neuron migration; nervous system development; negative regulation of dendrite development; axon guidance; multicellular organism development; negative regulation of collateral sprouting; regulation of neuron death; extrinsic apoptotic signaling pathway in absence of ligand; spinal cord ventral commissure morphogenesis; anterior/posterior axon guidance; apoptotic process; negative regulation of netrin-activated signaling pathway; postsynaptic modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	1630
	13176
	ENSG00000187323
	ENSMUSG00000060534
	P43146
	P70211
	NM_005215
	NM_007831
	NP_005206
	NP_031857
	Wikidata
View/Edit Human	View/Edit Mouse

Netrin receptor DCC, also known as DCC, or colorectal cancer suppressor is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer and its previous name was Deleted in colorectal carcinoma. Netrin receptor DCC is a single transmembrane receptor.

Since it was first discovered in a colorectal cancer study in 1990, DCC has been the focus of a significant amount of research. DCC held a controversial place as a tumour suppressor gene for many years, and is well known as an axon guidance receptor that responds to netrin-1.

More recently DCC has been characterized as a dependence receptor, and many hypotheses have been put forward that have revived interest in DCC's candidacy as a tumour suppressor gene, as it may be a ligand-dependent suppressor that is frequently epigenetically silenced.

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