U7 small nuclear RNA
The U7 small nuclear RNA (U7 snRNA) is an RNA molecule and a component of the small nuclear ribonucleoprotein complex (U7 snRNP). The U7 snRNA is required for histone pre-mRNA processing.
| U7 small nuclear RNA | |
|---|---|
Predicted secondary structure and sequence conservation of U7 | |
| Identifiers | |
| Symbol | U7 |
| Rfam | RF00066 |
| Other data | |
| RNA type | Gene; snRNA |
| Domain(s) | Eukaryota |
| SO | SO:0000274 |
| PDB structures | PDBe |
The 5' end of the U7 snRNA binds the HDE (histone downstream element), a conserved purine-rich region, located 15 nucleotides downstream the histone mRNA cleavage site. The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future recruitment of cleavage factors during histone pre-mRNA processing.
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