snRNP70

SNRNP70
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L5I, 2L5J, 3CW1, 3PGW, 4PJO, 4PKD
Identifiers
Aliases	SNRNP70, RNPU1Z, RPU1, SNRP70, Snp1, U1-70K, U170K, U1AP, U1RNP, SnRNP70, small nuclear ribonucleoprotein U1 subunit 70
External IDs	OMIM: 180740 MGI: 98341 HomoloGene: 20672 GeneCards: SNRNP70
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,108,605 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,045,166 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; canal of the cervix; ; body of pancreas; ; left uterine tube; ; anterior pituitary; ; body of stomach; ; minor salivary gland;
	Top expressed in
	superior frontal gyrus; ; yolk sac; ; lip; ; thymus; ; cerebellar cortex; ; abdominal wall; ; spermatocyte; ; maxillary prominence; ; crypt of lieberkuhn of small intestine; ; olfactory bulb;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; mRNA binding; U1 snRNP binding; U1 snRNA binding; RNA binding;
Cellular component	nuclear speck; nucleoplasm; precatalytic spliceosome; spliceosomal complex; commitment complex; U2-type prespliceosome; nucleus; U1 snRNP; cytoplasm;
Biological process	mRNA splicing, via spliceosome; positive regulation of mRNA splicing, via spliceosome; mRNA processing; negative regulation of chaperone-mediated autophagy; regulation of RNA splicing; RNA splicing; regulation of ATP-dependent activity; negative regulation of protein refolding; cellular response to tumor necrosis factor; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus;
	Sources:Amigo / QuickGO
Orthologs
	6625
	20637
	ENSG00000104852
	ENSMUSG00000063511
	P08621
	Q62376
	NM_001009820; NM_001301069; NM_003089
	NM_009224
	NP_001287998; NP_003080
	NP_033250
	Wikidata
View/Edit Human	View/Edit Mouse

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

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