U.S. Route 395

U.S. Route 395 (US 395), also known as U.S. Highway 395, is a north–south United States Numbered Highway that traverses the inland areas of the western states of California, Nevada, Oregon, and Washington. It travels for over 1,300 miles (2,100 km) from a junction in the Mojave Desert at Interstate 15 (I-15) in Hesperia to the Canada–U.S. border near Laurier, Washington. Major cities along its route include Carson City and Reno in Nevada; Kennewick and Pasco in Washington's Tri-Cities region; and Spokane, Washington. US 395 is an auxiliary route of US 95 but never intersects its parent route, which runs further east.

Originally created in 1926 as a spur route of US 195, the highway was extended south from Spokane to San Diego in the 1930s. It was named the Three Flags Highway to recognize its role in linking Mexico, the United States, and Canada. US 395 was truncated to its present southern terminus at Hesperia in 1964; its former alignment to San Diego was replaced by I-15, I-215, and other highways. Other sections were moved to freeways and bypasses of various cities, including I-82 between Oregon and Washington, I-90 in Eastern Washington, and I-580 in Nevada. The highway generally follows the east side of the Sierra Nevada mountain range in California and Nevada and also traverses the High Desert of eastern Oregon and the Columbia Plateau in Washington.