Tropicamide

Tropicamide
Clinical data
Trade names	Mydriacyl, others
AHFS/Drugs.com	Monograph
License data	US DailyMed: Tropicamide;
Pregnancy; category	C;
Routes of; administration	Topical eye drops
ATC code	S01FA06 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Protein binding	45%
Identifiers
	IUPAC name (RS)-N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide;
CAS Number	1508-75-4 ;
PubChem CID	5593;
IUPHAR/BPS	7319;
DrugBank	DB00809 ;
ChemSpider	5391 ;
UNII	N0A3Z5XTC6;
KEGG	D00397 ;
ChEMBL	ChEMBL1200604 ;
CompTox Dashboard (EPA)	DTXSID8045220 ;
ECHA InfoCard	100.014.673
Chemical and physical data
Formula	C17H20N2O2
Molar mass	284.359 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1;
	InChI InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3; Key:BGDKAVGWHJFAGW-UHFFFAOYSA-N;
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Tropicamide, sold under the brand name Mydriacyl among others, is a medication used to dilate the pupil and help with examination of the eye. Specifically it is used to help examine the back of the eye. It is applied as eye drops. Effects occur within 40 minutes and last for up to a day.

Common side effects include blurry vision, increased intraocular pressure, and sensitivity to light. Another rare but severe side effect is psychosis, particularly in children. It is unclear if use during pregnancy is safe for the fetus. Tropicamide is in the antimuscarinic part of the anticholinergic family of medications. It works by making the muscles within the eye unable to respond to nerve signals.

Tropicamide was approved for medical use in the United States in 1960. It is on the World Health Organization's List of Essential Medicines.

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