Tropomyosin receptor kinase B

NTRK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4
Identifiers
Aliases	NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE58
External IDs	OMIM: 600456 MGI: 97384 HomoloGene: 4504 GeneCards: NTRK2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	85,027,070 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	59,281,784 bp
RNA expression pattern
	Top expressed in
	optic nerve; ; external globus pallidus; ; Region I of hippocampus proper; ; internal globus pallidus; ; superior vestibular nucleus; ; ventral tegmental area; ; postcentral gyrus; ; amygdala; ; subthalamic nucleus; ; caudate nucleus;
	Top expressed in
	median eminence; ; arcuate nucleus; ; dorsomedial hypothalamic nucleus; ; superior frontal gyrus; ; substantia nigra; ; subiculum; ; dorsal tegmental nucleus; ; paraventricular nucleus of hypothalamus; ; globus pallidus; ; nucleus accumbens;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	neurotrophin binding; neurotrophin receptor activity; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein kinase activity; brain-derived neurotrophic factor binding; transferase activity; protein homodimerization activity; protein tyrosine kinase activity; nucleotide binding; brain-derived neurotrophic factor-activated receptor activity; protein binding; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	cytosol; endosome; postsynaptic membrane; membrane; terminal bouton; integral component of membrane; receptor complex; endosome membrane; integral component of plasma membrane; postsynaptic density; early endosome; early endosome membrane; plasma membrane; axon; dendrite; perinuclear region of cytoplasm; cytoplasm; cell projection; dendritic spine; axon terminus; Golgi membrane;
Biological process	negative regulation of neuron apoptotic process; peripheral nervous system neuron development; positive regulation of protein phosphorylation; oligodendrocyte differentiation; learning; positive regulation of axonogenesis; vasculogenesis; protein phosphorylation; central nervous system neuron development; neuromuscular junction development; retinal rod cell development; circadian rhythm; feeding behavior; regulation of GTPase activity; positive regulation of peptidyl-serine phosphorylation; brain-derived neurotrophic factor receptor signaling pathway; regulation of protein kinase B signaling; regulation of metabolic process; positive regulation of MAPK cascade; cell differentiation; phosphorylation; neuron migration; mechanoreceptor differentiation; nervous system development; glutamate secretion; retina development in camera-type eye; neuron differentiation; cerebral cortex development; negative regulation of anoikis; multicellular organism development; positive regulation of gene expression; positive regulation of cell population proliferation; positive regulation of neuron projection development; cellular response to amino acid stimulus; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; long-term potentiation; positive regulation of synapse assembly; transmembrane receptor protein tyrosine kinase signaling pathway; protein autophosphorylation; trans-synaptic signaling by neuropeptide, modulating synaptic transmission; activation of phospholipase C activity; neurotrophin TRK receptor signaling pathway; positive regulation of non-membrane spanning protein tyrosine kinase activity; trans-synaptic signaling by BDNF, modulating synaptic transmission; negative regulation of signal transduction; neuronal action potential propagation; myelination in peripheral nervous system; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; cellular response to nerve growth factor stimulus; regulation of MAPK cascade; cellular response to brain-derived neurotrophic factor stimulus;
	Sources:Amigo / QuickGO
Orthologs
	4915
	18212
	ENSG00000148053
	ENSMUSG00000055254
	Q16620
	P15209
NM_001007097; NM_001018064; NM_001018065; NM_001018066; NM_001291937;
	NM_006180
	NM_001025074; NM_008745; NM_001282961
NP_001007098; NP_001018074; NP_001018075; NP_001018076; NP_001278866;
	NP_006171; NP_001356461; NP_001356462; NP_001356463; NP_001356464; NP_001356465; NP_001356466; NP_001356467; NP_001356468; NP_001356469; NP_001356470; NP_001356471; NP_001356472; NP_001356473; NP_001356474; NP_001356475; NP_001356476; NP_001356477; NP_001356478; NP_001356479; NP_001356480; NP_001356481
	NP_001020245; NP_001269890; NP_032771
	Wikidata
View/Edit Human	View/Edit Mouse

Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. TrkB is a receptor for brain-derived neurotrophic factor (BDNF). The standard pronunciation for this protein is "track bee".

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