Tribendimidine

Tribendimidine
Clinical data
ATC code	none;
Identifiers
	IUPAC name N,N-bis(4-(1-dimethylamino)ethylideneaminophenyl)-1,4; -phenylene dimethylidyneamine;
CAS Number	115103-15-6 ;
PubChem CID	3086564;
ChemSpider	2343161 ;
UNII	YO6SOD6ZTJ;
ChEMBL	ChEMBL427256 ;
CompTox Dashboard (EPA)	DTXSID50894077 ;
Chemical and physical data
Formula	C28H32N6
Molar mass	452.606 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N(=C/c2ccc(\C=N\c1ccc(/N=C(/N(C)C)C)cc1)cc2)\c3ccc(\N=C(\N(C)C)C)cc3;
	InChI InChI=1S/C28H32N6/c1-21(33(3)4)31-27-15-11-25(12-16-27)29-19-23-7-9-24(10-8-23)20-30-26-13-17-28(18-14-26)32-22(2)34(5)6/h7-20H,1-6H3/b29-19+,30-20+,31-21+,32-22+ ; Key:XOIOGKHKNQYULW-HTNNXBMUSA-N ;
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Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.

In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis. It is also effective against clonorchiasis. However, animal studies suggest it is ineffective in treating Schistosoma mansoni or Fasciola hepatica disease. The drug has also performed well in trials against opisthorchiasis, curing about 70% of cases.

Tribendimidine is manufactured by Shandong Xinhua Pharmaceutical Company Limited in Zibo, Shandong, China. It was approved by the China Food and Drug Administration in 2007.

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