Trastuzumab

Trastuzumab
	Trastuzumab Fab region (cyan) binding HER2/neu (gold)
Monoclonal antibody
Type	Whole antibody
Source	Humanized (from mouse)
Target	HER2/neu
Clinical data
Trade names	Herceptin, Herceptin SC, others
Biosimilars	trastuzumab-anns, trastuzumab-dkst, trastuzumab-dttb, trastuzumab-pkrb, trastuzumab-qyyp, Herzuma, Herwenda, Kanjinti, Ogivri, Ontruzant, Trastucip, Trazimera, Tuzucip, Zercepac
AHFS/Drugs.com	Monograph
License data	EU EMA: by INN; US DailyMed: Trastuzumab; US FDA: Trastuzumab;
Pregnancy; category	AU: D;
Routes of; administration	Intravenous, subcutaneous
Drug class	Antineoplastic agent
ATC code	L01FD01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only / Schedule D; US: WARNINGRx-only; EU: Rx-only;
Pharmacokinetic data
Metabolism	Unknown, possibly reticuloendothelial system
Elimination half-life	2-12 days
Identifiers
CAS Number	180288-69-1 ;
PubChem SID	46507516;
DrugBank	DB00072 ;
ChemSpider	none;
UNII	P188ANX8CK;
KEGG	D03257 ;
ChEMBL	ChEMBL1201585 ;
ECHA InfoCard	100.224.377
Chemical and physical data
Formula	C6470H10012N1726O2013S42
Molar mass	145531.86 g·mol−1
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Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. It is specifically used for cancer that is HER2 receptor positive. It may be used by itself or together with other chemotherapy medication. Trastuzumab is given by slow injection into a vein and injection just under the skin.

Common side effects include fever, infection, cough, headache, trouble sleeping, and rash. Other severe side effects include heart failure, allergic reactions, and lung disease. Use during pregnancy may harm the baby. Trastuzumab works by binding to the HER2 receptor and slowing down cell replication.

Trastuzumab was approved for medical use in the United States in September 1998, and in the European Union in August 2000. It is on the World Health Organization's List of Essential Medicines.

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