Transporter associated with antigen processing

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
Symbol	TAP2
Alt. symbols	ABCB3
NCBI gene	6891
HGNC	44
OMIM	170261
RefSeq	NM_000544
UniProt	Q03519
Other data
Locus	Chr. 6 p21.3
Structures
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Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
Symbol	TAP1
Alt. symbols	ABCB2
NCBI gene	6890
HGNC	43
OMIM	170260
RefSeq	NM_000593
UniProt	Q03518
Other data
Locus	Chr. 6 p21.3
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Transporter associated with antigen processing (TAP) protein complex belongs to the ATP-binding-cassette transporter family. It delivers cytosolic peptides into the endoplasmic reticulum (ER), where they bind to nascent MHC class I molecules.

The TAP structure is formed of two proteins: TAP-1 and TAP-2, which have one hydrophobic region and one ATP-binding region each. They assemble into a heterodimer, which results in a four-domain transporter.

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