Transcription factor II E

Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.

general transcription factor IIE, polypeptide 1, alpha 56kDa
Identifiers
SymbolGTF2E1
Alt. symbolsTF2E1
NCBI gene2960
HGNC4650
OMIM189962
RefSeqNM_005513
UniProtP29083
Other data
LocusChr. 3 q21-q24
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StructuresSwiss-model
DomainsInterPro
general transcription factor IIE, polypeptide 2, beta 34kDa
Identifiers
SymbolGTF2E2
Alt. symbolsTF2E2
NCBI gene2961
HGNC4651
OMIM189964
RefSeqNM_002095
UniProtP29084
Other data
LocusChr. 8 p12
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StructuresSwiss-model
DomainsInterPro

TFIIE recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes. TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.

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