Topotecan

Topotecan
Clinical data
Trade names	Hycamtin, Potactasol
AHFS/Drugs.com	Monograph
MedlinePlus	a610007
License data	EU EMA: by INN; US DailyMed: Topotecan;
Pregnancy; category	AU: D;
Routes of; administration	Intravenous infusion, by mouth (capsules)
ATC code	L01CE01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: WARNINGRx-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	31.4 % in humans
Protein binding	35%
Metabolism	Liver
Elimination half-life	2–3 hours
Excretion	Kidney
Identifiers
	IUPAC name (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride;
CAS Number	123948-87-8 119413-54-6 (hydrochloride);
PubChem CID	60700;
IUPHAR/BPS	7101;
DrugBank	DB01030 ;
ChemSpider	54705 ;
UNII	7M7YKX2N15;
KEGG	D08618 ; D02168;
ChEMBL	ChEMBL84 ;
CompTox Dashboard (EPA)	DTXSID3042685 ;
ECHA InfoCard	100.213.372
Chemical and physical data
Formula	C23H23N3O5
Molar mass	421.453 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C\1N4\C(=C/C2=C/1COC(=O)[C@]2(O)CC)c3nc5c(cc3C4)c(c(O)cc5)CN(C)C;
	InChI InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1 ; Key:UCFGDBYHRUNTLO-QHCPKHFHSA-N ;
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Topotecan, sold under the brand name Hycamtin among others, is a chemotherapeutic agent medication that is a topoisomerase inhibitor. It is a synthetic, water-soluble analog of the natural chemical compound camptothecin. It is used in the form of its hydrochloride salt to treat ovarian cancer, lung cancer and other cancer types.

After GlaxoSmithKline received final FDA approval for topotecan on October 15, 2007, it became the first topoisomerase I inhibitor for oral use.

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