Thyroid hormone receptor alpha

THRA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NAV, 2H77, 2H79, 3HZF, 3ILZ, 3JZB, 4LNW, 4LNX
Identifiers
Aliases	THRA, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor, alpha, thyroid hormone receptor alpha, TRalpha
External IDs	OMIM: 190120 MGI: 98742 HomoloGene: 37747 GeneCards: THRA
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,093,867 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,659,832 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; middle frontal gyrus; ; amygdala; ; caudate nucleus; ; putamen; ; cingulate gyrus; ; cerebellar hemisphere; ; Brodmann area 9; ; prefrontal cortex; ; sural nerve;
	Top expressed in
	entorhinal cortex; ; superior frontal gyrus; ; subiculum; ; hippocampus proper; ; cerebellar cortex; ; olfactory tubercle; ; Region I of hippocampus proper; ; superior colliculus; ; inferior colliculus; ; primary motor cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription cis-regulatory region binding; protein binding; single-stranded RNA binding; zinc ion binding; chromatin DNA binding; nuclear receptor activity; steroid receptor RNA activator RNA binding; transcription factor binding; TBP-class protein binding; steroid hormone receptor activity; DNA binding; protein domain specific binding; sequence-specific DNA binding; metal ion binding; DNA-binding transcription factor activity; thyroid hormone binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein-containing complex binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; nuclear receptor coactivator activity; signaling receptor activity;
Cellular component	cytoplasm; nucleoplasm; nucleus; cytosol; RNA polymerase II transcription regulator complex;
Biological process	regulation of transcription by RNA polymerase II; response to cold; cytoplasmic sequestering of transcription factor; hormone-mediated signaling pathway; regulation of thyroid hormone mediated signaling pathway; thyroid gland development; regulation of transcription, DNA-templated; ossification; female courtship behavior; cartilage condensation; negative regulation of RNA polymerase II transcription preinitiation complex assembly; type I pneumocyte differentiation; transcription, DNA-templated; steroid hormone mediated signaling pathway; transcription by RNA polymerase II; regulation of lipid catabolic process; regulation of heart contraction; animal organ morphogenesis; positive regulation of female receptivity; learning or memory; regulation of myeloid cell apoptotic process; positive regulation of transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter; erythrocyte differentiation; negative regulation of DNA-templated transcription, initiation; positive regulation of myotube differentiation; negative regulation of transcription, DNA-templated; intracellular receptor signaling pathway; negative regulation of transcription by RNA polymerase II; thyroid hormone mediated signaling pathway; multicellular organism development; brain development; cell differentiation; response to lipid; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7067
	21833
	ENSG00000126351
	ENSMUSG00000058756
	P10827
	P63058
	NM_199334; NM_001190918; NM_001190919; NM_003250
	NM_178060; NM_001313983
	NP_001177847; NP_001177848; NP_003241; NP_955366
	NP_001300912; NP_835161
	Wikidata
View/Edit Human	View/Edit Mouse

Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear receptor protein that in humans is encoded by the THRA gene.

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