Thymosin beta-4

TMSB4X
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4PL7, 4PL8
Identifiers
Aliases	TMSB4X, FX, PTMB4, TB4X, TMSB4, thymosin beta 4, X-linked, thymosin beta 4 X-linked
External IDs	OMIM: 300159 GeneCards: TMSB4X
Gene location (Human)
Chr.	X chromosome (human)
End	12,977,227 bp
RNA expression pattern
	Top expressed in
	monocyte; ; stromal cell of endometrium; ; ganglionic eminence; ; lymph node; ; gallbladder; ; appendix; ; right lung; ; upper lobe of left lung; ; blood; ; ascending aorta;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; RNA binding; actin monomer binding; enzyme binding;
Cellular component	cytoskeleton; platelet alpha granule lumen; intracellular anatomical structure; nucleus; cytoplasm; cytosol; extracellular region;
Biological process	platelet degranulation; actin filament organization; cytoplasmic sequestering of NF-kappaB; negative regulation of NF-kappaB transcription factor activity; tumor necrosis factor-mediated signaling pathway; sequestering of actin monomers; positive regulation of blood vessel endothelial cell migration; regulation of inflammatory response; regulation of NIK/NF-kappaB signaling; negative regulation of NIK/NF-kappaB signaling; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; positive regulation of proton-transporting ATP synthase activity, rotational mechanism; positive regulation of endothelial cell chemotaxis; positive regulation of ATP biosynthetic process; osteoblast differentiation; regulation of cell migration;
	Sources:Amigo / QuickGO
Orthologs
	7114
	n/a
	ENSG00000205542
	n/a
	P62328
	n/a
	NM_021109
	n/a
	NP_066932
	n/a
	Wikidata
View/Edit Human

Thymosin beta-4 is a protein that in humans is encoded by the TMSB4X gene. Recommended INN (International Nonproprietary Name) for thymosin beta-4 is 'timbetasin', as published by the World Health Organization (WHO).

The protein consists (in humans) of 43 amino acids (sequence: SDKPDMAEI EKFDKSKLKK TETQEKNPLP SKETIEQEKQ AGES) and has a molecular weight of 4921 g/mol.

Thymosin-β₄ is a major cellular constituent in many tissues. Its intracellular concentration may reach as high as 0.5 mM. Following Thymosin α1, β₄ was the second of the biologically active peptides from Thymosin Fraction 5 to be completely sequenced and synthesized.

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