Tetrahydroisoquinoline

Tetrahydroisoquinoline (TIQ or THIQ) is an organic compound with the chemical formula C9H11N. Classified as a secondary amine, it is derived from isoquinoline by hydrogenation. It is a colorless viscous liquid that is miscible with most organic solvents. The tetrahydroisoquinoline skeleton is encountered in a number of bioactive compounds and drugs.

This article is about the simple heterocyclic amine. For the selective MC4 agonist, see THIQ.
Tetrahydroisoquinoline
Names
Preferred IUPAC name
1,2,3,4-Tetrahydroisoquinoline
Identifiers
3D model (JSmol)
Abbreviations TIQ, THIQ
ChEMBL
ChemSpider
ECHA InfoCard 100.001.864
EC Number
  • 202-050-0
RTECS number
  • NX4900000
UNII
  • InChI=1S/C9H11N/c1-2-4-9-7-10-6-5-8(9)3-1/h1-4,10H,5-7H2 Y
    Key: UWYZHKAOTLEWKK-UHFFFAOYSA-N Y
  • InChI=1/C9H11N/c1-2-4-9-7-10-6-5-8(9)3-1/h1-4,10H,5-7H2
    Key: UWYZHKAOTLEWKK-UHFFFAOYAB
  • c1ccc2c(c1)CCNC2
Properties
C9H11N
Molar mass 133.19 g/mol
Appearance Deep yellow liquid
Density 1.05 g/mL
Melting point −30 °C (−22 °F; 243 K)
Boiling point 235 to 239 °C (455 to 462 °F; 508 to 512 K)
Hazards
GHS labelling:
Danger
H301, H310, H314, H332, H371, H412
P260, P261, P262, P264, P270, P271, P273, P280, P301+P310, P301+P330+P331, P302+P350, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P309+P311, P310, P312, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, P501
Flash point 99 °C (210 °F; 372 K) (closed cup)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is YN ?)
Infobox references
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