Tetherin

BST2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2LK9, 2X7A, 2XG7, 3MQ7, 3MQ9, 3MQB, 3MQC, 3NWH, 4P6Z
Identifiers
Aliases	BST2, CD317, TETHERIN, Tetherin, bone marrow stromal cell antigen 2, HM1.24
External IDs	OMIM: 600534 HomoloGene: 48277 GeneCards: BST2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,405,630 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; left uterine tube; ; monocyte; ; spleen; ; right uterine tube; ; peritoneum; ; gallbladder; ; right lobe of liver; ; pericardium; ; gastric mucosa;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; signal transducer activity; protein binding; metalloendopeptidase inhibitor activity; RNA binding; identical protein binding;
Cellular component	cytoplasm; integral component of membrane; multivesicular body; endosome; late endosome; Golgi apparatus; membrane; plasma membrane; integral component of plasma membrane; cell surface; apical plasma membrane; membrane raft; anchored component of membrane; extracellular exosome; cytosol; azurophil granule membrane;
Biological process	negative regulation of intracellular transport of viral material; regulation of actin cytoskeleton organization; response to interferon-gamma; immune system process; cell-cell signaling; response to virus; response to interferon-beta; multicellular organism development; B cell activation; negative regulation of viral genome replication; negative regulation of cell migration; humoral immune response; defense response to virus; type I interferon signaling pathway; negative regulation of cell growth; negative regulation of plasmacytoid dendritic cell cytokine production; response to interferon-alpha; positive regulation of I-kappaB kinase/NF-kappaB signaling; cell population proliferation; innate immune response; negative regulation of endopeptidase activity; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	684
	n/a
	ENSG00000130303
	n/a
	Q10589
	n/a
	NM_004335
	n/a
	NP_004326
	n/a
	Wikidata
View/Edit Human

Tetherin, also known as bone marrow stromal antigen 2, is a lipid raft associated protein that in humans is encoded by the BST2 gene. In addition, tetherin has been designated as CD317 (cluster of differentiation 317). This protein is constitutively expressed in mature B cells, plasma cells and plasmacytoid dendritic cells, and in many other cells, it is only expressed as a response to stimuli from IFN pathway.

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