Testolactone

Testolactone (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name) (brand name Teslac) is a non-selective, irreversible, steroidal aromatase inhibitor which is used as an antineoplastic drug to treat advanced-stage breast cancer. The drug was discontinued in 2008 and is no longer available for medical use.

Testolactone
Clinical data
Trade namesTeslac
Other names13-Hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid δ-lactone; SQ-9538; Fludestrin; NSC-12173; NSC-23759
AHFS/Drugs.comConsumer Drug Information
Routes of
administration		By mouth
Drug classAromatase inhibitor; Antiestrogen
ATC code
  • none
Pharmacokinetic data
Protein binding~85%
MetabolismLiver
ExcretionUrine
Identifiers
  • (4aS,4bR,10aR,10bS,12aS)-10a,12a-Dimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydro-2H-naphtho[2,1-f]chromene-2,8(4bH)-dione
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.012.304
Chemical and physical data
FormulaC19H24O3
Molar mass300.398 g·mol−1
3D model (JSmol)
  • CC12CCC3C(C1CCC(=O)O2)CCC4=CC(=O)C=CC34C
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