Tachykinin receptor 1

TACR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KSB, 2KS9, 2KSA
Identifiers
Aliases	TACR1, NK1R, NKIR, SPR, TAC1R, tachykinin receptor 1
External IDs	OMIM: 162323 MGI: 98475 HomoloGene: 20288 GeneCards: TACR1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	75,199,520 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	82,537,085 bp
RNA expression pattern
	Top expressed in
	canal of the cervix; ; subcutaneous adipose tissue; ; left uterine tube; ; Achilles tendon; ; smooth muscle tissue; ; vagina; ; tibial nerve; ; putamen; ; caudate nucleus; ; gastric mucosa;
	Top expressed in
	main bronchus; ; lens; ; superior frontal gyrus; ; trachea; ; thyroid gland; ; stomach; ; neural tube; ; axial skeleton; ; cerebellar cortex; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	tachykinin receptor activity; G protein-coupled receptor activity; signal transducer activity; protein binding; substance P receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; cell periphery; cytoplasm; cell surface; dendrite; cell body; sperm flagellum; sperm head; sperm midpiece;
Biological process	regulation of uterine smooth muscle contraction; phospholipase C-activating G protein-coupled receptor signaling pathway; response to pain; detection of abiotic stimulus; inflammatory response; positive regulation of smooth muscle contraction; signal transduction; chemical synaptic transmission; aggressive behavior; acute inflammatory response; positive regulation of leukocyte migration; angiotensin-mediated drinking behavior; learning or memory; long-term memory; regulation of blood pressure; associative learning; response to heat; response to hormone; response to ozone; positive regulation of epithelial cell migration; response to auditory stimulus; response to organic cyclic compound; regulation of smooth muscle cell migration; sensory perception of pain; positive regulation of synaptic transmission, cholinergic; positive regulation of synaptic transmission, GABAergic; response to estradiol; response to progesterone; response to nicotine; operant conditioning; positive regulation of renal sodium excretion; ejaculation; eating behavior; positive regulation of vascular permeability; response to morphine; response to ethanol; positive regulation of action potential; positive regulation of blood pressure; positive regulation of ossification; positive regulation of vasoconstriction; positive regulation of saliva secretion; positive regulation of hormone secretion; behavioral response to pain; regulation of smooth muscle cell proliferation; positive regulation of lymphocyte proliferation; positive regulation of epithelial cell proliferation; positive regulation of stress fiber assembly; response to electrical stimulus; smooth muscle contraction involved in micturition; positive regulation of uterine smooth muscle contraction; positive regulation of cytosolic calcium ion concentration; tachykinin receptor signaling pathway; positive regulation of flagellated sperm motility; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6869
	21336
	ENSG00000115353
	ENSMUSG00000030043
	P25103
	P30548
	NM_015727; NM_001058
	NM_009313
	NP_001049; NP_056542
	NP_033339
	Wikidata
View/Edit Human	View/Edit Mouse

The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene.

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