TSPAN7
Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene.
| TSPAN7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | TSPAN7, A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, TALLA-1, TM4SF2, TM4SF2b, tetraspanin 7, XLID58 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 300096 MGI: 1298407 HomoloGene: 20967 GeneCards: TSPAN7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. More recently, it has been identified as a key immune system target in type 1 diabetes.