TSC2

TSC2
Identifiers
Aliases	TSC2, LAM, PPP1R160, TSC4, tuberous sclerosis 2, TSC complex subunit 2
External IDs	OMIM: 191092 MGI: 102548 HomoloGene: 462 GeneCards: TSC2
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,089,491 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,851,604 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right uterine tube; ; right lobe of thyroid gland; ; sural nerve; ; left lobe of thyroid gland; ; gastric mucosa; ; canal of the cervix; ; ganglionic eminence; ; body of stomach; ; left uterine tube;
	Top expressed in
	superior frontal gyrus; ; entorhinal cortex; ; interventricular septum; ; lens; ; plantaris muscle; ; extensor digitorum longus muscle; ; extraocular muscle; ; cerebellar cortex; ; yolk sac; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatase binding; protein homodimerization activity; GTPase activator activity; small GTPase binding; protein binding; Hsp90 protein binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; membrane; TSC1-TSC2 complex; perinuclear region of cytoplasm; lysosome; nucleus; postsynaptic density;
Biological process	regulation of endocytosis; protein localization; insulin-like growth factor receptor signaling pathway; negative regulation of protein kinase B signaling; endocytosis; protein import into nucleus; negative regulation of protein kinase activity; negative regulation of Wnt signaling pathway; negative regulation of phosphatidylinositol 3-kinase signaling; regulation of cell cycle; heart development; positive regulation of GTPase activity; neural tube closure; negative regulation of insulin receptor signaling pathway; positive chemotaxis; viral process; regulation of small GTPase mediated signal transduction; vesicle-mediated transport; negative regulation of cell population proliferation; regulation of insulin receptor signaling pathway; positive regulation of macroautophagy; anoikis; negative regulation of mitophagy; negative regulation of TOR signaling; protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	7249
	22084
	ENSG00000103197
	ENSMUSG00000002496
	P49815
	Q61037
NM_000548; NM_001077183; NM_001114382; NM_021055; NM_021056;
	NM_001318827; NM_001318829; NM_001318831; NM_001318832; NM_001363528; NM_001370404; NM_001370405
NM_001039363; NM_001286713; NM_001286714; NM_001286716; NM_001286718;
	NM_001286720; NM_011647
NP_000539; NP_001070651; NP_001107854; NP_001305756; NP_001305758;
	NP_001305760; NP_001305761; NP_066399; NP_001350457; NP_001357333; NP_001357334
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Tuberous Sclerosis Complex 2 (TSC2), also known as Tuberin, is a protein that in humans is encoded by the TSC2 gene.

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