MCOLN3

MCOLN3
Identifiers
Aliases	MCOLN3, TRP-ML3, TRPML3, mucolipin 3, mucolipin TRP cation channel 3
External IDs	OMIM: 607400 MGI: 1890500 HomoloGene: 10118 GeneCards: MCOLN3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	85,048,500 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	145,847,561 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; corpus epididymis; ; germinal epithelium; ; pituitary gland; ; anterior pituitary; ; body of pancreas; ; caput epididymis; ; visceral pleura; ; Achilles tendon; ; canal of the cervix;
	Top expressed in
	stria vascularis; ; yolk sac; ; utricle; ; iris; ; medullary collecting duct; ; hair follicle; ; otic placode; ; respiratory epithelium; ; olfactory epithelium; ; cochlea;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel activity; lipid binding; cation channel activity; NAADP-sensitive calcium-release channel activity;
Cellular component	plasma membrane; membrane; cytoplasm; integral component of membrane; autophagosome membrane; lysosome; lysosomal membrane; endosome; cytoplasmic vesicle; early endosome membrane; late endosome membrane;
Biological process	inner ear auditory receptor cell differentiation; ion transport; locomotory behavior; calcium ion transmembrane transport; release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologs
	55283
	171166
	ENSG00000055732
	ENSMUSG00000036853
	Q8TDD5
	Q8R4F0
	NM_001253693; NM_018298
	NM_134160
	NP_001240622; NP_060768
	NP_598921
	Wikidata
View/Edit Human	View/Edit Mouse

Mucolipin-3 also known as TRPML3 (transient receptor potential cation channel, mucolipin subfamily, member 3) is a protein that in humans is encoded by the MCOLN3 gene. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

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