MCOLN2

MCOLN2
Identifiers
Aliases	MCOLN2, TRP-ML2, TRPML2, mucolipin 2, mucolipin TRP cation channel 2
External IDs	OMIM: 607399 MGI: 1915529 HomoloGene: 12258 GeneCards: MCOLN2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	84,997,113 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	145,901,268 bp
RNA expression pattern
	Top expressed in
	tibia; ; rectum; ; lymph node; ; left adrenal gland; ; secondary oocyte; ; spleen; ; right uterine tube; ; germinal epithelium; ; upper lobe of left lung; ; appendix;
	Top expressed in
	yolk sac; ; duodenum; ; spleen; ; jejunum; ; colon; ; left colon; ; spermatid; ; Paneth cell; ; blood; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel activity; cation channel activity; NAADP-sensitive calcium-release channel activity;
Cellular component	integral component of membrane; membrane; lysosome; lysosomal membrane; endosome; plasma membrane; late endosome membrane; recycling endosome membrane; recycling endosome;
Biological process	ion transport; adaptive immune response; immune system process; calcium ion transport; protein transport; innate immune response; calcium ion transmembrane transport; positive regulation of chemokine production; protein complex oligomerization; positive regulation of monocyte chemotactic protein-1 production; positive regulation of macrophage inflammatory protein 1 alpha production; positive regulation of chemokine (C-C motif) ligand 5 production; macrophage migration; neutrophil migration; positive regulation of chemokine (C-X-C motif) ligand 2 production; release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologs
	255231
	68279
	ENSG00000153898
	ENSMUSG00000011008
	Q8IZK6
	Q8K595
	NM_153259; NM_001330647
	NM_001005846; NM_026656
	NP_001317576; NP_694991
	NP_001005846; NP_080932
	Wikidata
View/Edit Human	View/Edit Mouse

Mucolipin-2 also known as TRPML2 (transient receptor potential cation channel, mucolipin subfamily, member 2) is a protein that in humans is encoded by the MCOLN2 gene. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

TRPML2 is associated with the Arf6-regulated trafficking pathway and is involved in the intracellular transport of membranes and membrane proteins.

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