TREM1

TREM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Q8M, 1SMO
Identifiers
Aliases	TREM1, CD354, TREM-1, triggering receptor expressed on myeloid cells 1
External IDs	OMIM: 605085 MGI: 1930005 HomoloGene: 10243 GeneCards: TREM1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	41,286,682 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	48,553,952 bp
RNA expression pattern
	Top expressed in
	monocyte; ; periodontal fiber; ; blood; ; right lung; ; upper lobe of left lung; ; lower lobe of lung; ; bone marrow; ; bone marrow cells; ; spleen; ; appendix;
	Top expressed in
	bone marrow; ; secondary oocyte; ; spermatid; ; lung; ; spleen; ; duodenum; ; jejunum; ; male reproductive system; ; testicle; ; liver;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	scaffold protein binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular region; intracellular anatomical structure;
Biological process	intracellular signal transduction; humoral immune response; regulation of immune response; innate immune response; leukocyte migration; acute inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	54210
	58217
	ENSG00000124731
	ENSMUSG00000042265
	Q9NP99
	Q9JKE2
	NM_001242589; NM_001242590; NM_018643
	NM_021406; NM_001347399
	NP_001229518; NP_001229519; NP_061113
	NP_001334328; NP_067381
	Wikidata
View/Edit Human	View/Edit Mouse

Triggering receptor expressed on myeloid cells 1 (TREM1) is an immunoglobulin (Ig) superfamily transmembrane protein that, in humans, is encoded by the TREM1 gene. TREM1 is constitutively expressed on the surface of peripheral blood monocytes and neutrophils, and upregulated by toll-like receptor (TLR) ligands; activation of TREM1 amplifies immune responses.

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