TRAF4

TRAF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EOD, 2YUC, 3ZJB, 4K8U, 4M4E
Identifiers
Aliases	TRAF4, CART1, MLN62, RNF83, TNF receptor associated factor 4
External IDs	OMIM: 602464 MGI: 1202880 HomoloGene: 3173 GeneCards: TRAF4
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,750,956 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,056,415 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; minor salivary gland; ; left lobe of thyroid gland; ; right lobe of liver; ; ganglionic eminence; ; gallbladder; ; rectum; ; body of pancreas; ; body of stomach;
	Top expressed in
	yolk sac; ; neural tube; ; ganglionic eminence; ; proximal tubule; ; somite; ; thymus; ; maxillary prominence; ; hand; ; trigeminal ganglion; ; secondary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; metal ion binding; protein binding; WW domain binding; thioesterase binding; tumor necrosis factor receptor binding; protein kinase binding; ubiquitin protein ligase binding; identical protein binding;
Cellular component	cytoplasm; membrane; bicellular tight junction; plasma membrane; cell junction; perinuclear region of cytoplasm; cytoskeleton; nucleus; protein-containing complex; intracellular anatomical structure;
Biological process	regulation of apoptotic process; activation of NF-kappaB-inducing kinase activity; positive regulation of JNK cascade; positive regulation of protein homodimerization activity; respiratory gaseous exchange by respiratory system; multicellular organism development; respiratory tube development; signal transduction; positive regulation of protein kinase activity; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	9618
	22032
	ENSG00000076604
	ENSMUSG00000017386
	Q9BUZ4
	Q61382
	NM_004295; NM_145751
	NM_009423
	NP_004286
	NP_033449
	Wikidata
View/Edit Human	View/Edit Mouse

TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.

TRAF4 is a member of the TNF receptor associated factor (TRAF) family, a family of scaffold proteins. TRAF proteins connect IL-1R/Toll and TNF receptors with signaling factors that lead to the activation of NF-κB and mitogen-activated protein kinases. However, TRAF4 is not known to interact with TNF receptors and its cellular functions are not well understood.

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