TOLLIP

TOLLIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGL, 2N31
Identifiers
Aliases	TOLLIP, IL-1RAcPIP, toll interacting protein
External IDs	OMIM: 606277 MGI: 1891808 HomoloGene: 10375 GeneCards: TOLLIP
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,309,654 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,472,244 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; dorsolateral prefrontal cortex; ; right lobe of liver; ; Brodmann area 9; ; amygdala; ; skin of abdomen; ; anterior pituitary; ; gastrocnemius muscle; ; middle temporal gyrus; ; nucleus accumbens;
	Top expressed in
	spermatocyte; ; ankle joint; ; cumulus cell; ; spermatid; ; olfactory epithelium; ; cerebellar cortex; ; seminiferous tubule; ; medial dorsal nucleus; ; superior frontal gyrus; ; pituitary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; Toll-like receptor binding; SUMO binding; kinase binding; protein binding; interleukin-1, type I receptor binding; ubiquitin protein ligase binding; ubiquitin conjugating enzyme binding; ubiquitin binding;
Cellular component	interleukin-18 receptor complex; cytosol; nuclear body; perinuclear region of cytoplasm; interleukin-1 receptor complex; extracellular exosome; extracellular region; cytoplasm; azurophil granule lumen; specific granule lumen;
Biological process	intracellular signal transduction; epithelial cell differentiation; phosphorylation; immune system process; leukocyte activation; cell-cell signaling; positive regulation of protein sumoylation; autophagy; protein localization to endosome; innate immune response; inflammatory response; signal transduction; ubiquitin-dependent protein catabolic process; neutrophil degranulation; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	54472
	54473
	ENSG00000078902
	ENSMUSG00000025139
	Q9H0E2; Q6FIE9
	Q9QZ06
	NM_019009; NM_001318512; NM_001318514; NM_001318515; NM_001318516
	NM_023764; NM_001347562
NP_001305441; NP_001305443; NP_001305444; NP_001305445; NP_061882;
	NP_061882.2
	NP_001334491; NP_076253
	Wikidata
View/Edit Human	View/Edit Mouse

Toll interacting protein, also known as TOLLIP, is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene.

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