Tankyrase 2

TNKS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Y0I, 3KR7, 3KR8, 3MHJ, 3MHK, 3P0N, 3P0P, 3P0Q, 3TWQ, 3TWR, 3TWS, 3TWT, 3TWU, 3TWV, 3TWW, 3TWX, 3U9H, 3U9Y, 3UA9, 3W51, 4AVU, 4AVW, 4BFP, 4BJ9, 4BJB, 4BJC, 4BS4, 4BU3, 4BU5, 4BU6, 4BU7, 4BU8, 4BU9, 4BUA, 4BUD, 4BUE, 4BUF, 4BUI, 4BUS, 4BUT, 4BUU, 4BUV, 4BUW, 4BUX, 4BUY, 4HKI, 4HKK, 4HKN, 4HL5, 4HLF, 4HLG, 4HLH, 4HLK, 4HLM, 4HMH, 4HYF, 4IUE, 4J1Z, 4J21, 4J22, 4J3L, 4J3M, 4KZL, 4KZQ, 4KZU, 4L09, 4L0B, 4L0I, 4L0S, 4L0T, 4L0V, 4L10, 4L2F, 4L2G, 4L2K, 4L31, 4L32, 4L33, 4L34, 4M7B, 4PML, 4PNL, 4PNM, 4PNN, 4PNQ, 4PNR, 4PNS, 4PNT, 4TJU, 4TJW, 4TJY, 4TK0, 4TK5, 4TKF, 4TKG, 4TKI, 4UVL, 4UVN, 4UVO, 4UVP, 4UVS, 4UVT, 4UVU, 4UVV, 4UVW, 4UVX, 4UVY, 4UVZ, 4UX4, 4W5I, 5AKU, 5AKW, 5AL1, 5AL2, 5AL3, 5AL4, 5AL5, 5C5P, 5C5Q, 5C5R, 5ADT, 5ADS, 5ADQ, 5AEH, 5ADR, 4Z68, 5BXU, 4UI5, 4UFY, 4UI7, 4UI3, 4UI4, 4UFU, 4UHG, 4UI6, 5BXO, 4UI8
Identifiers
Aliases	TNKS2, ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6, tankyrase 2
External IDs	OMIM: 607128 MGI: 1921743 HomoloGene: 11890 GeneCards: TNKS2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	91,865,475 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	36,870,877 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; triceps brachii muscle; ; superior surface of tongue; ; body of tongue; ; superficial temporal artery; ; placenta; ; Region I of hippocampus proper; ; trigeminal ganglion; ; caput epididymis; ; seminal vesicula;
	Top expressed in
	primitive streak; ; renal corpuscle; ; aortic valve; ; medullary collecting duct; ; ascending aorta; ; retinal pigment epithelium; ; urothelium; ; ciliary body; ; maxillary prominence; ; cumulus cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; metal ion binding; protein binding; enzyme binding; NAD+ ADP-ribosyltransferase activity; protein ADP-ribosylase activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; pericentriolar material; nuclear envelope; membrane; Golgi membrane; chromosome; telomere; perinuclear region of cytoplasm; nucleus;
Biological process	protein auto-ADP-ribosylation; protein ADP-ribosylation; positive regulation of telomere capping; multicellular organism growth; regulation of multicellular organism growth; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; positive regulation of telomere maintenance via telomerase; protein localization to chromosome, telomeric region; negative regulation of telomere maintenance via telomere lengthening; Wnt signaling pathway; protein poly-ADP-ribosylation;
	Sources:Amigo / QuickGO
Orthologs
	80351
	74493
	ENSG00000107854
	ENSMUSG00000024811
	Q9H2K2
	Q3UES3
	NM_025235
	NM_001163635
	NP_079511
	NP_001157107
	Wikidata
View/Edit Human	View/Edit Mouse

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.

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