TNFSF12

TNFSF12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HT1
Identifiers
Aliases	TNFSF12, APO3L, DR3LG, TWEAK, TNLG4A, tumor necrosis factor superfamily member 12, TNF superfamily member 12
External IDs	OMIM: 602695 MGI: 1196259 HomoloGene: 7979 GeneCards: TNFSF12
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,557,890 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,586,675 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; thoracic aorta; ; ascending aorta; ; left coronary artery; ; popliteal artery; ; gastric mucosa; ; left uterine tube; ; fundus; ; amygdala; ; subcutaneous adipose tissue;
	Top expressed in
	lip; ; ankle; ; right lung; ; ascending aorta; ; aortic valve; ; esophagus; ; right lung lobe; ; morula; ; soleus muscle; ; retinal pigment epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding; tumor necrosis factor receptor binding; signaling receptor binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; perinuclear region of cytoplasm; extracellular space;
Biological process	cell differentiation; positive regulation of endothelial cell proliferation; positive regulation of protein catabolic process; extrinsic apoptotic signaling pathway; tumor necrosis factor-mediated signaling pathway; positive regulation of angiogenesis; multicellular organism development; angiogenesis; immune response; apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway; endothelial cell migration; signal transduction; apoptotic process; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	8742
	21944
	ENSG00000239697
	ENSMUSG00000097328
	O43508
	O54907
	NM_003809
	NM_011614
	NP_003800
	NP_035744
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein that in humans is encoded by the TNFSF12 gene.

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