TNFRSF18

TNFRSF18
Identifiers
Aliases	TNFRSF18, AITR, CD357, GITR, GITR-D, tumor necrosis factor receptor superfamily member 18, TNF receptor superfamily member 18, ENERGEN
External IDs	OMIM: 603905 MGI: 894675 HomoloGene: 48270 GeneCards: TNFRSF18
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,206,592 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	156,113,352 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; tibialis anterior muscle; ; spleen; ; blood; ; appendix; ; bone marrow cells; ; minor salivary gland; ; canal of the cervix; ; lymph node; ; deltoid muscle;
	Top expressed in
	thymus; ; blood; ; lip; ; spleen; ; zone of skin; ; skin of abdomen; ; ascending aorta; ; aortic valve; ; skin of back; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	tumor necrosis factor-activated receptor activity; protein binding;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; membrane;
Biological process	apoptotic process; multicellular organism development; response to lipopolysaccharide; inflammatory response; tumor necrosis factor-mediated signaling pathway; regulation of cell population proliferation; immune response; signal transduction; positive regulation of leukocyte migration; negative regulation of apoptotic process; regulation of apoptotic process; apoptotic signaling pathway; positive regulation of tyrosine phosphorylation of STAT protein; regulation of regulatory T cell differentiation; positive regulation of cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	8784
	21936
	ENSG00000186891
	ENSMUSG00000041954
	Q9Y5U5
	O35714
	NM_148902; NM_004195; NM_148901
	NM_009400; NM_021985
	NP_004186; NP_683699; NP_683700
	NP_033426; NP_068820
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as glucocorticoid-induced TNFR-related protein (GITR) or CD357. GITR is encoded and tnfrsf18 gene at chromosome 4 in mice. GITR is type I transmembrane protein and is described in 4 different isoforms. GITR human orthologue, also called activation-inducible TNFR family receptor (AITR), is encoded by the TNFRSF18 gene at chromosome 1.

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