TNFRSF12A

TNFRSF12A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EQP, 2KMZ, 2RPJ
Identifiers
Aliases	TNFRSF12A, CD266, FN14, TWEAKR, tumor necrosis factor receptor superfamily member 12A, TNF receptor superfamily member 12A
External IDs	OMIM: 605914 MGI: 1351484 HomoloGene: 8451 GeneCards: TNFRSF12A
Gene location (Human)
Chr.	Chromosome 16 (human)
End	3,022,383 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	23,896,442 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; body of pancreas; ; anterior pituitary; ; gallbladder; ; right coronary artery; ; upper lobe of left lung; ; left ventricle; ; left coronary artery; ; right ventricle; ; left uterine tube;
	Top expressed in
	interventricular septum; ; adrenal gland; ; soleus muscle; ; lip; ; yolk sac; ; right ventricle; ; calvaria; ; left ventricle; ; cardiac muscles; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	ruffle; integral component of membrane; cell surface; plasma membrane; membrane;
Biological process	apoptotic process; substrate-dependent cell migration, cell attachment to substrate; multicellular organism development; positive regulation of extrinsic apoptotic signaling pathway; cell differentiation; positive regulation of axon extension; cell adhesion; tumor necrosis factor-mediated signaling pathway; regulation of wound healing; regulation of angiogenesis; extrinsic apoptotic signaling pathway; angiogenesis; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	51330
	27279
	ENSG00000006327
	ENSMUSG00000023905
	Q9NP84
	Q9CR75
	NM_016639
	NM_001161746; NM_013749
	NP_057723
	NP_001155218; NP_038777
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene.

Other names used when talking about TNFRSF12A are fibroblast growth factor-inducible immediate-early response protein 14 (FN14). TNFRSF12A is a unique member of the Tumor Necrosis Factor Receptor superfamily. TNFRSF12A is the smallest member of the Tumor Necrosis Factor Receptor superfamily and the gene expression is highly regulated in a live organism and a petri dish. TNFRSF12A is the receptor for the TWEAK which is its ligand. Many other members of the Tumor necrosis factor superfamily can bind to other ligands but this receptor can only bind to TNFRSF12. TNFRSF12A is found in many human tissues, including the heart, placenta, lung, skeletal muscle, kidney, and pancreas. It is involved in several biological processes, such as inflammatory reactions, angiogenesis, cell proliferation, and cell death.

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