Toll-like receptor 7

TLR7
Identifiers
Aliases	TLR7, TLR7-like, toll like receptor 7, IMD74, SLEB17
External IDs	OMIM: 300365 MGI: 2176882 HomoloGene: 75060 GeneCards: TLR7
Gene location (Human)
Chr.	X chromosome (human)
End	12,890,361 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	166,113,554 bp
RNA expression pattern
	Top expressed in
	monocyte; ; lymph node; ; appendix; ; gallbladder; ; parietal pleura; ; rectum; ; right coronary artery; ; placenta; ; visceral pleura; ; blood;
	Top expressed in
	spleen; ; calvaria; ; blood; ; subcutaneous adipose tissue; ; thymus; ; superior frontal gyrus; ; ascending aorta; ; visual cortex; ; aortic valve; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane signaling receptor activity; double-stranded RNA binding; siRNA binding; single-stranded RNA binding; pattern recognition receptor activity;
Cellular component	integral component of membrane; Golgi membrane; cytoplasmic vesicle; early phagosome; endosome; receptor complex; phagocytic vesicle; membrane; lysosome; endoplasmic reticulum; plasma membrane; endolysosome membrane; cytoplasm; endosome membrane; endoplasmic reticulum membrane;
Biological process	I-kappaB phosphorylation; immune system process; positive regulation of inflammatory response; toll-like receptor 9 signaling pathway; positive regulation of interleukin-8 production; toll-like receptor signaling pathway; regulation of protein phosphorylation; defense response to virus; cellular response to mechanical stimulus; microglial cell activation; positive regulation of interleukin-6 production; MyD88-dependent toll-like receptor signaling pathway; signal transduction; positive regulation of chemokine production; immune response; toll-like receptor 7 signaling pathway; innate immune response; inflammatory response; positive regulation of NIK/NF-kappaB signaling; I-kappaB kinase/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	51284
	170743
	ENSG00000196664
	ENSMUSG00000044583
	Q9NYK1
	P58681
	NM_016562
	NM_133211; NM_001290755; NM_001290756; NM_001290757; NM_001290758
	NP_057646
	NP_001277684; NP_001277685; NP_001277686; NP_001277687; NP_573474
	Wikidata
View/Edit Human	View/Edit Mouse

Toll-like receptor 7, also known as TLR7, is a protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds. It is a member of the toll-like receptor (TLR) family and detects single stranded RNA.

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