Toll-like receptor 6

TLR6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OM7
Identifiers
Aliases	TLR6, CD286, toll like receptor 6
External IDs	OMIM: 605403 MGI: 1341296 HomoloGene: 21223 GeneCards: TLR6
Gene location (Human)
Chr.	Chromosome 4 (human)
End	38,856,817 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	65,117,440 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; lymph node; ; spleen; ; appendix; ; bone marrow cells; ; Achilles tendon; ; thymus; ; gallbladder; ; stromal cell of endometrium;
	Top expressed in
	blood; ; spleen; ; thymus; ; calvaria; ; carotid body; ; skeletal muscle tissue; ; white adipose tissue; ; duodenum; ; superior frontal gyrus; ; lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	Toll-like receptor 2 binding; protein binding; transmembrane signaling receptor activity; lipopeptide binding; amyloid-beta binding; signaling receptor binding; signaling receptor activity; identical protein binding; protein heterodimerization activity;
Cellular component	integral component of membrane; phagocytic vesicle membrane; membrane; integral component of plasma membrane; cytoplasmic vesicle; Golgi apparatus; membrane raft; Toll-like receptor 2-Toll-like receptor 6 protein complex; plasma membrane; intracellular anatomical structure; receptor complex;
Biological process	positive regulation of NLRP3 inflammasome complex assembly; immune system process; positive regulation of JUN kinase activity; cellular response to diacyl bacterial lipopeptide; activation of NF-kappaB-inducing kinase activity; toll-like receptor 6 signaling pathway; defense response to bacterium; positive regulation of I-kappaB kinase/NF-kappaB signaling; inflammatory response; toll-like receptor TLR6:TLR2 signaling pathway; detection of diacyl bacterial lipopeptide; signal transduction; innate immune response; T-helper 1 type immune response; MyD88-dependent toll-like receptor signaling pathway; nitric oxide metabolic process; response to bacterial lipoprotein; microglial cell activation; toll-like receptor signaling pathway; cell activation; immune response; positive regulation of gene expression; negative regulation of toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; positive regulation of macrophage activation; positive regulation of nitric oxide biosynthetic process; positive regulation of NF-kappaB transcription factor activity; cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of cytokine production involved in inflammatory response; positive regulation of oxidative stress-induced neuron death; positive regulation of reactive oxygen species biosynthetic process; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	10333
	21899
	ENSG00000174130
	ENSMUSG00000051498
	Q9Y2C9
	Q9EPW9
	NM_006068; NM_001394553
	NM_011604; NM_001359180; NM_001384171
	NP_006059
	NP_035734; NP_001346109; NP_001371100
	Wikidata
View/Edit Human	View/Edit Mouse

Toll-like receptor 6 is a protein that in humans is encoded by the TLR6 gene. TLR6 is a transmembrane protein, member of toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. TLR6 acts in a heterodimer form with toll-like receptor 2 (TLR2). Its ligands include multiple diacyl lipopeptides derived from gram-positive bacteria and mycoplasma and several fungal cell wall saccharides. After dimerizing with TLR2, the NF-κB intracellular signalling pathway is activated, leading to a pro-inflammatory cytokine production and activation of innate immune response. TLR6 has also been designated as CD286 (cluster of differentiation 286).

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