Toll-like receptor 3

TLR3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA
Identifiers
Aliases	TLR3, CD283, IIAE2, toll like receptor 3, IMD83
External IDs	OMIM: 603029 MGI: 2156367 HomoloGene: 20696 GeneCards: TLR3
Gene location (Human)
Chr.	Chromosome 4 (human)
End	186,088,073 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	45,864,117 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; palpebral conjunctiva; ; placenta; ; rectum; ; sperm; ; duodenum; ; gallbladder; ; Achilles tendon; ; pancreatic epithelial cell; ; pancreatic ductal cell;
	Top expressed in
	conjunctival fornix; ; stria vascularis; ; secondary oocyte; ; jejunum; ; utricle; ; aortic valve; ; duodenum; ; Paneth cell; ; large intestine; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding; RNA binding; double-stranded RNA binding; transmembrane signaling receptor activity; signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; endosome; endoplasmic reticulum membrane; membrane; Golgi membrane; integral component of plasma membrane; intracellular anatomical structure; cell surface; lysosomal membrane; early endosome; endoplasmic reticulum; endolysosome membrane; endosome membrane; extracellular space; extracellular matrix;
Biological process	positive regulation of interferon-beta production; response to dsRNA; defense response; positive regulation of toll-like receptor signaling pathway; positive regulation of protein phosphorylation; male gonad development; positive regulation of inflammatory response; positive regulation of interleukin-12 production; positive regulation of type III interferon production; cellular response to interferon-beta; response to exogenous dsRNA; negative regulation of osteoclast differentiation; positive regulation of cytokine production; immune system process; response to virus; activation of NF-kappaB-inducing kinase activity; I-kappaB phosphorylation; positive regulation of JNK cascade; hyperosmotic response; cellular response to dsRNA; regulation of dendritic cell cytokine production; microglial cell activation; toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cellular response to mechanical stimulus; microglial cell activation involved in immune response; positive regulation of gene expression; defense response to bacterium; positive regulation of NF-kappaB transcription factor activity; defense response to virus; necroptotic signaling pathway; positive regulation of interleukin-8 production; cellular response to exogenous dsRNA; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; cellular response to interferon-gamma; positive regulation of chemokine production; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; detection of virus; inflammatory response; innate immune response; I-kappaB kinase/NF-kappaB signaling; toll-like receptor 3 signaling pathway; positive regulation of type I interferon production; MyD88-independent toll-like receptor signaling pathway; signal transduction; positive regulation of transcription by RNA polymerase II; necroptosis; apoptotic signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; extrinsic apoptotic signaling pathway; positive regulation of angiogenesis; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	7098
	142980
	ENSG00000164342
	ENSMUSG00000031639
	O15455
	Q99MB1
	NM_003265
	NM_126166; NM_001357316; NM_001357317
	NP_003256
	NP_569054; NP_001344245; NP_001344246
	Wikidata
View/Edit Human	View/Edit Mouse

Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3 recognizes double-stranded RNA in endosomes, which is a common feature of viral genomes internalised by macrophages and dendritic cells.

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