Toll-like receptor 2

TLR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FYW, 1FYX, 1O77, 2Z7X, 2Z80
Identifiers
Aliases	TLR2, CD282, TIL4, toll like receptor 2
External IDs	OMIM: 603028 MGI: 1346060 HomoloGene: 20695 GeneCards: TLR2
Gene location (Human)
Chr.	Chromosome 4 (human)
End	153,706,260 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	83,749,074 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; right lung; ; upper lobe of left lung; ; spleen; ; bone marrow; ; bone marrow cells; ; periodontal fiber; ; appendix; ; lower lobe of lung;
	Top expressed in
	right lung lobe; ; calvaria; ; islet of Langerhans; ; conjunctival fornix; ; cervix; ; carotid body; ; renal corpuscle; ; large intestine; ; colon; ; cornea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	pattern recognition receptor activity; lipopolysaccharide binding; Toll-like receptor binding; triacyl lipopeptide binding; protein binding; peptidoglycan binding; protein heterodimerization activity; lipopolysaccharide immune receptor activity; transmembrane signaling receptor activity; lipopeptide binding;
Cellular component	cytoplasm; integral component of membrane; phagocytic vesicle membrane; Golgi apparatus; membrane; intrinsic component of plasma membrane; plasma membrane; Toll-like receptor 1-Toll-like receptor 2 protein complex; integral component of plasma membrane; membrane raft; cytoplasmic vesicle; cell projection; cell surface; cell body;
Biological process	interleukin-10 production; positive regulation of interferon-beta production; defense response to Gram-positive bacterium; positive regulation of interleukin-18 production; positive regulation of toll-like receptor signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; positive regulation of inflammatory response; cellular response to bacterial lipopeptide; positive regulation of interleukin-12 production; immune system process; detection of diacyl bacterial lipopeptide; cellular response to diacyl bacterial lipopeptide; I-kappaB phosphorylation; positive regulation of nitric-oxide synthase biosynthetic process; MyD88-dependent toll-like receptor signaling pathway; cellular response to triacyl bacterial lipopeptide; detection of triacyl bacterial lipopeptide; positive regulation of Wnt signaling pathway; positive regulation of gene expression; cellular response to lipoteichoic acid; positive regulation of NF-kappaB transcription factor activity; immune response; positive regulation of interleukin-8 production; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of chemokine production; innate immune response; inflammatory response; toll-like receptor TLR6:TLR2 signaling pathway; response to molecule of bacterial origin; signal transduction; positive regulation of transcription by RNA polymerase II; apoptotic process; response to lipopolysaccharide; response to progesterone; toll-like receptor signaling pathway; response to insulin; central nervous system myelin formation; nitric oxide metabolic process; response to fatty acid; leukotriene metabolic process; toll-like receptor 2 signaling pathway; positive regulation of oligodendrocyte differentiation; response to bacterial lipoprotein; negative regulation of cell population proliferation; response to toxic substance; response to hypoxia; positive regulation of interleukin-10 production; lipopolysaccharide-mediated signaling pathway; microglial cell activation;
	Sources:Amigo / QuickGO
Orthologs
	7097
	24088
	ENSG00000137462
	ENSMUSG00000027995
	O60603
	Q9QUN7
NM_003264; NM_001318787; NM_001318789; NM_001318790; NM_001318791;
	NM_001318793; NM_001318795; NM_001318796
	NM_011905
NP_001305716; NP_001305718; NP_001305719; NP_001305720; NP_001305722;
	NP_001305724; NP_001305725; NP_003255
	NP_036035
	Wikidata
View/Edit Human	View/Edit Mouse

Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene. TLR2 has also been designated as CD282 (cluster of differentiation 282). TLR2 is one of the toll-like receptors and plays a role in the immune system. TLR2 is a membrane protein, a receptor, which is expressed on the surface of certain cells and recognizes foreign substances and passes on appropriate signals to the cells of the immune system.

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