Toll-like receptor 10

TLR10
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2J67
Identifiers
Aliases	TLR10, CD290, toll like receptor 10
External IDs	OMIM: 606270 HomoloGene: 12809 GeneCards: TLR10
Gene location (Human)
Chr.	Chromosome 4 (human)
End	38,782,990 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; spleen; ; blood; ; monocyte; ; thymus; ; bone marrow cells; ; superficial temporal artery; ; rectum; ; gallbladder;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane signaling receptor activity; protein binding; identical protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	toll-like receptor 10 signaling pathway; inflammatory response; positive regulation of inflammatory response; MyD88-dependent toll-like receptor signaling pathway; signal transduction; immune system process; innate immune response; toll-like receptor signaling pathway; immune response;
	Sources:Amigo / QuickGO
Orthologs
	81793
	n/a
	ENSG00000174123
	n/a
	Q9BXR5
	n/a
	NM_001017388; NM_001195106; NM_001195107; NM_001195108; NM_030956
	n/a
	NP_001017388; NP_001182035; NP_001182036; NP_001182037; NP_112218
	n/a
	Wikidata
View/Edit Human

Toll-like receptor 10 is a protein that in humans is encoded by the TLR10 gene. TLR10 has also been designated as CD290 (cluster of differentiation 290). TLR10 has not been extensively studied because it is a pseudogene in mice, though all other mammalian species contain an intact copy of the TLR10 gene. Unlike other TLRs, TLR10 does not activate the immune system and has instead been shown to suppress inflammatory signaling on primary human cells. This makes TLR10 unique among the TLR family. TLR10 was thought to be an "orphan" receptor, however, recent studies have identified ligands for TLR10 and these include HIV-gp41. Ligands for TLR2 are potential ligands for TLR10.

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