TIMD4

TIMD4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5F7H, 5DZN, 5F7F
Identifiers
Aliases	TIMD4, SMUCKLER, TIM4, T-cell immunoglobulin and mucin domain containing 4, T cell immunoglobulin and mucin domain containing 4
External IDs	OMIM: 610096 MGI: 2445125 HomoloGene: 51381 GeneCards: TIMD4
Gene location (Human)
Chr.	Chromosome 5 (human)
End	156,963,226 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	46,735,159 bp
RNA expression pattern
	Top expressed in
	sperm; ; lymph node; ; oocyte; ; spongy bone; ; synovial joint; ; superficial temporal artery; ; spleen; ; appendix; ; secondary oocyte; ; synovial membrane;
	Top expressed in
	spleen; ; secondary oocyte; ; subcutaneous adipose tissue; ; mammary gland; ; white adipose tissue; ; liver; ; esophagus; ; thymus; ; left lobe of liver; ; lip;
	More reference expression data
	n/a
Orthologs
	91937
	276891
	ENSG00000145850
	ENSMUSG00000055546
	Q96H15
	Q6U7R4
	NM_001146726; NM_138379
	NM_178759
	NP_001140198; NP_612388
	NP_848874
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene. TIM-4 genes are in mouse present on chromosome 11B1.1 and in humans on chromosome 5q33.2. TIM-4 contains IgV domain with integrin-binding site as well as a unique metal-ion-dependent ligand binding site for phosphatidylserine. TIM-4 also contains mucin domain with high levels of O-glycosylation. In comparison to other TIM proteins (such as TIM-1, TIM-2...) it does not contain a tyrosine-phosphorylation motif in its intracellular tail domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.