Tetrahydrofuran
Tetrahydrofuran (THF), or oxolane, is an organic compound with the formula (CH2)4O. The compound is classified as heterocyclic compound, specifically a cyclic ether. It is a colorless, water-miscible organic liquid with low viscosity. It is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent.
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| Names | |||
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| Preferred IUPAC name
Oxolane | |||
| Systematic IUPAC name
1,4-Epoxybutane 1-Oxacyclopentane | |||
| Other names
Tetrahydrofuran THF 1,4-Butylene oxide Cyclotetramethylene oxide fraction Furanidin Tetra-methylene oxide, Oxolane | |||
| Identifiers | |||
3D model (JSmol) |
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| Abbreviations | THF | ||
| ChEBI | |||
| ChEMBL | |||
| ChemSpider | |||
| ECHA InfoCard | 100.003.389 | ||
PubChem CID |
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| RTECS number |
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| UNII | |||
CompTox Dashboard (EPA) |
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| Properties | |||
| C4H8O | |||
| Molar mass | 72.107 g·mol−1 | ||
| Appearance | Colorless liquid | ||
| Odor | Ether-like | ||
| Density | 0.8876 g/cm3 at 20 °C, liquid | ||
| Melting point | −108.4 °C (−163.1 °F; 164.8 K) | ||
| Boiling point | 66 °C (151 °F; 339 K) | ||
| Miscible | |||
| Vapor pressure | 132 mmHg (20 °C) | ||
Refractive index (nD) |
1.4073 (20 °C) | ||
| Viscosity | 0.48 cP at 25 °C | ||
| Structure | |||
| Envelope | |||
| 1.63 D (gas) | |||
| Hazards | |||
| GHS labelling: | |||
| Danger | |||
| H225, H302, H319, H335, H351 | |||
| P210, P280, P301+P312+P330, P305+P351+P338, P370+P378, P403+P235 | |||
| NFPA 704 (fire diamond) | |||
| Flash point | −14 °C (7 °F; 259 K) | ||
| Explosive limits | 2–11.8% | ||
| Lethal dose or concentration (LD, LC): | |||
LD50 (median dose) |
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LC50 (median concentration) |
21000 ppm (rat, 3 h) | ||
| NIOSH (US health exposure limits): | |||
PEL (Permissible) |
TWA 200 ppm (590 mg/m3) | ||
REL (Recommended) |
TWA 200 ppm (590 mg/m3) ST 250 ppm (735 mg/m3) | ||
IDLH (Immediate danger) |
2000 ppm | ||
| Related compounds | |||
Related heterocycles |
Furan Pyrrolidine Dioxane | ||
Related compounds |
Diethyl ether | ||
| Supplementary data page | |||
| Tetrahydrofuran (data page) | |||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references | |||
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