TGFBR3

TGFBR3
Identifiers
Aliases	TGFBR3, BGCAN, betaglycan, transforming growth factor beta receptor 3
External IDs	OMIM: 600742 MGI: 104637 HomoloGene: 2436 GeneCards: TGFBR3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	91,906,335 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	107,437,495 bp
RNA expression pattern
	Top expressed in
	glomerulus; ; metanephric glomerulus; ; synovial joint; ; Achilles tendon; ; lactiferous duct; ; tibia; ; seminal vesicula; ; nipple; ; urethra; ; pericardium;
	Top expressed in
	ciliary body; ; iris; ; conjunctival fornix; ; retinal pigment epithelium; ; carotid body; ; ankle; ; belly cord; ; intercostal muscle; ; dermis; ; left lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transforming growth factor beta receptor binding; heparin binding; activin binding; transforming growth factor beta receptor activity, type III; transforming growth factor beta-activated receptor activity; SMAD binding; PDZ domain binding; coreceptor activity; fibroblast growth factor binding; type II transforming growth factor beta receptor binding; protein binding; glycosaminoglycan binding; transforming growth factor beta binding;
Cellular component	extracellular exosome; extracellular region; cytoplasm; integral component of membrane; inhibin-betaglycan-ActRII complex; integral component of plasma membrane; membrane; cell surface; receptor complex; plasma membrane; external side of plasma membrane; extracellular space; extracellular matrix;
Biological process	response to hypoxia; heart trabecula formation; intracellular signal transduction; liver development; animal organ regeneration; definitive erythrocyte differentiation; BMP signaling pathway; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of protein binding; heart morphogenesis; transforming growth factor beta receptor complex assembly; cardiac epithelial to mesenchymal transition; pathway-restricted SMAD protein phosphorylation; response to follicle-stimulating hormone; ventricular cardiac muscle tissue morphogenesis; roof of mouth development; cardiac muscle cell proliferation; response to prostaglandin E; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of epithelial cell proliferation; cell migration; definitive hemopoiesis; epithelial to mesenchymal transition; response to luteinizing hormone; immune response; transforming growth factor beta receptor signaling pathway; epicardium-derived cardiac fibroblast cell development; ventricular septum morphogenesis; regulation of ERK1 and ERK2 cascade; ventricular compact myocardium morphogenesis; heart trabecula morphogenesis; positive regulation of cardiac muscle cell proliferation; regulation of JNK cascade; muscular septum morphogenesis; vasculogenesis involved in coronary vascular morphogenesis; outflow tract morphogenesis; secondary palate development; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	7049
	21814
	ENSG00000069702
	ENSMUSG00000029287
	Q03167
	O88393
	NM_001195683; NM_001195684; NM_003243
	NM_011578
	NP_001182612; NP_001182613; NP_003234
	NP_035708
	Wikidata
View/Edit Human	View/Edit Mouse

Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. TGFBR3 is the most widely expressed type of TGF-beta receptor. Its affinity towards all individual isoforms of TGF-beta is similarly high and therefore it plays an important role as a coreceptor mediating the binding of TGF-beta to its other receptors - specifically TGFBR2. The intrinsic kinase activity of this receptor has not yet been described. In regard of TGF-beta signalling it is generally considered a non-signaling receptor or a coreceptor. By binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of TGF-beta.

Study of a mouse knock-out for the Tgfbr3 gene showed a fundamental effect on the correct development of organs and the overall viability of the animals used. Within the same study, no significant changes in Smad signalling (typical for TGF-beta cascade) were detected. This fact suggests that additional, as yet undescribed functions of betaglycan may be mediated by non-classical signalling pathways.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.