TGF beta receptor 1

TGFBR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B6C, 1IAS, 1PY5, 1RW8, 1VJY, 2L5S, 2PJY, 2WOT, 2WOU, 2X7O, 3FAA, 3GXL, 3HMM, 3KCF, 3KFD, 3TZM, 4X0M, 4X2J, 4X2K, 4X2N, 4X2G, 4X2F, 5E8W, 5E8X, 5E8U, 5E8T, 5E8S, 5E90, 5E8Z
Identifiers
Aliases	TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I, transforming growth factor beta receptor 1, TBRI, TBR-i
External IDs	OMIM: 190181 MGI: 98728 HomoloGene: 3177 GeneCards: TGFBR1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	99,154,192 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	47,414,931 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; tibia; ; visceral pleura; ; Achilles tendon; ; synovial joint; ; lactiferous duct; ; ganglionic eminence; ; superficial temporal artery; ; spinal ganglia; ; amniotic fluid;
	Top expressed in
	medullary collecting duct; ; superior cervical ganglion; ; cumulus cell; ; medial ganglionic eminence; ; abdominal wall; ; maxillary prominence; ; molar; ; body of femur; ; atrium; ; foot;
	More reference expression data
	n/a
Gene ontology
Molecular function	type II transforming growth factor beta receptor binding; I-SMAD binding; transforming growth factor beta-activated receptor activity; kinase activity; signaling receptor binding; ATP binding; protein kinase activity; metal ion binding; protein serine/threonine kinase activity; transforming growth factor beta receptor activity, type I; transferase activity; growth factor binding; transmembrane receptor protein serine/threonine kinase activity; protein binding; SMAD binding; nucleotide binding; transforming growth factor beta binding; activin binding;
Cellular component	endosome; membrane; bicellular tight junction; cell surface; membrane raft; integral component of membrane; receptor complex; plasma membrane; cell junction; intracellular anatomical structure; intracellular membrane-bounded organelle; integral component of plasma membrane; activin receptor complex; nucleus;
Biological process	skeletal system development; response to cholesterol; regulation of protein ubiquitination; post-embryonic development; protein phosphorylation; negative regulation of chondrocyte differentiation; mesenchymal cell differentiation; angiogenesis; transforming growth factor beta receptor signaling pathway; positive regulation of filopodium assembly; extracellular structure organization; pharyngeal system development; apoptotic process; cellular response to transforming growth factor beta stimulus; pathway-restricted SMAD protein phosphorylation; positive regulation of protein kinase B signaling; regulation of transcription, DNA-templated; kidney development; collagen fibril organization; thymus development; cell motility; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of apoptotic signaling pathway; in utero embryonic development; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transcription, DNA-templated; heart development; positive regulation of cell growth; parathyroid gland development; artery morphogenesis; blastocyst development; activin receptor signaling pathway; roof of mouth development; cell differentiation; male gonad development; phosphorylation; skeletal system morphogenesis; wound healing; negative regulation of apoptotic process; epithelial to mesenchymal transition; regulation of gene expression; embryonic cranial skeleton morphogenesis; peptidyl-threonine phosphorylation; intracellular signal transduction; positive regulation of endothelial cell proliferation; positive regulation of cell migration; regulation of epithelial to mesenchymal transition; positive regulation of pathway-restricted SMAD protein phosphorylation; endothelial cell activation; negative regulation of endothelial cell proliferation; transmembrane receptor protein serine/threonine kinase signaling pathway; lens development in camera-type eye; peptidyl-serine phosphorylation; positive regulation of cell population proliferation; regulation of growth; neuron fate commitment; regulation of protein binding; endothelial cell migration; germ cell migration; positive regulation of SMAD protein signal transduction; cardiac epithelial to mesenchymal transition; signal transduction; anterior/posterior pattern specification; proepicardium development; ventricular trabecula myocardium morphogenesis; ventricular compact myocardium morphogenesis; positive regulation of epithelial to mesenchymal transition; protein deubiquitination; positive regulation of stress fiber assembly; regulation of cardiac muscle cell proliferation; ventricular septum morphogenesis; angiogenesis involved in coronary vascular morphogenesis; coronary artery morphogenesis; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of tight junction disassembly; epicardium morphogenesis; positive regulation of apoptotic process; positive regulation of gene expression; pattern specification process;
	Sources:Amigo / QuickGO
Orthologs
	7046
	21812
	ENSG00000106799
	ENSMUSG00000007613
	P36897
	Q64729
	NM_001130916; NM_001306210; NM_004612
	NM_009370; NM_001312868; NM_001312869
	NP_001124388; NP_001293139; NP_004603
	NP_001299797; NP_001299798; NP_033396
	Wikidata
View/Edit Human	View/Edit Mouse

Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound TGF beta receptor protein of the TGF-beta receptor family for the TGF beta superfamily of signaling ligands. TGFBR1 is its human gene.

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