Transforming growth factor, beta 3

TGFB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KTZ, 1TGJ, 1TGK, 2PJY, 3EO1, 4UM9
Identifiers
Aliases	TGFB3, ARVD, ARVD1, RNHF, TGF-beta3, Transforming growth factor, beta 3, LDS5, transforming growth factor beta 3, TGF beta 3
External IDs	OMIM: 190230 MGI: 98727 HomoloGene: 2433 GeneCards: TGFB3
Gene location (Human)
Chr.	Chromosome 14 (human)
End	75,983,011 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	86,125,815 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; canal of the cervix; ; gallbladder; ; prostate; ; smooth muscle tissue; ; body of pancreas; ; periodontal fiber; ; ascending aorta; ; vena cava; ; gastrocnemius muscle;
	Top expressed in
	external carotid artery; ; molar; ; aortic valve; ; internal carotid artery; ; ascending aorta; ; ankle; ; belly cord; ; ankle joint; ; calvaria; ; body of femur;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	type III transforming growth factor beta receptor binding; cytokine activity; type I transforming growth factor beta receptor binding; protein binding; protein heterodimerization activity; transforming growth factor beta receptor binding; growth factor activity; transforming growth factor beta binding; type II transforming growth factor beta receptor binding; identical protein binding;
Cellular component	cytoplasm; extracellular matrix; T-tubule; plasma membrane; secretory granule; cell surface; neuronal cell body; platelet alpha granule lumen; nucleus; extracellular region; extracellular space; intracellular membrane-bounded organelle; collagen-containing extracellular matrix;
Biological process	regulation of apoptotic process; negative regulation of neuron apoptotic process; positive regulation of collagen biosynthetic process; cell-cell junction organization; regulation of MAPK cascade; SMAD protein signal transduction; positive regulation of bone mineralization; embryonic neurocranium morphogenesis; response to progesterone; female pregnancy; response to laminar fluid shear stress; human ageing; platelet degranulation; in utero embryonic development; negative regulation of transforming growth factor beta receptor signaling pathway; wound healing; salivary gland morphogenesis; mammary gland development; odontogenesis; response to estrogen; positive regulation of protein secretion; ossification involved in bone remodeling; uterine wall breakdown; frontal suture morphogenesis; inner ear development; negative regulation of macrophage cytokine production; lung alveolus development; digestive tract development; transforming growth factor beta receptor signaling pathway; positive regulation of filopodium assembly; positive regulation of cell division; face morphogenesis; detection of hypoxia; positive regulation of transcription by RNA polymerase II; positive regulation of SMAD protein signal transduction; positive regulation of tight junction disassembly; positive regulation of epithelial to mesenchymal transition; positive regulation of stress fiber assembly; regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of apoptotic process; response to hypoxia; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of transcription, DNA-templated; negative regulation of vascular associated smooth muscle cell proliferation; BMP signaling pathway; cell development; regulation of signaling receptor activity; positive regulation of cell population proliferation; negative regulation of cell population proliferation; secondary palate development; regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	7043
	21809
	ENSG00000119699
	ENSMUSG00000021253
	P10600
	P17125
	NM_003239; NM_001329938; NM_001329939
	NM_009368
	NP_001316867; NP_001316868; NP_003230
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene.

It is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily, which includes the TGF-β family, Bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), inhibins and activins.

TGF-β3 is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate. This is caused by failure of epithelial cells in both sides of the developing palate to fuse. TGF-β3 also plays an essential role in controlling the development of lungs in mammals, by also regulating cell adhesion and ECM formation in this tissue, and controls wound healing by regulating the movements of epidermal and dermal cells in injured skin.

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