TGF beta 2

TGFB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TFG, 2TGI, 4KXZ
Identifiers
Aliases	TGFB2, LDS4, TGF-beta2, transforming growth factor beta 2, G-TSF
External IDs	OMIM: 190220 MGI: 98726 HomoloGene: 2432 GeneCards: TGFB2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	218,444,619 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	186,438,186 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; germinal epithelium; ; sperm; ; minor salivary gland; ; tibia; ; islet of Langerhans; ; smooth muscle tissue; ; right coronary artery; ; canal of the cervix; ; hair follicle;
	Top expressed in
	ciliary body; ; iris; ; external carotid artery; ; secondary oocyte; ; internal carotid artery; ; semi-lunar valve; ; submandibular gland; ; atrioventricular canal; ; pineal gland; ; ascending aorta;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	type II transforming growth factor beta receptor binding; signaling receptor binding; type III transforming growth factor beta receptor binding; cytokine activity; transforming growth factor beta receptor binding; growth factor activity; protein homodimerization activity; amyloid-beta binding; protein binding; protein heterodimerization activity;
Cellular component	extracellular region; extracellular matrix; platelet alpha granule lumen; extracellular space; axon; neuronal cell body; collagen-containing extracellular matrix;
Biological process	eye development; regulation of transforming growth factor beta2 production; response to progesterone; cell death; cardioblast differentiation; positive regulation of integrin biosynthetic process; protein phosphorylation; positive regulation of heart contraction; positive regulation of neuron apoptotic process; angiogenesis; negative regulation of epithelial cell proliferation; uterine wall breakdown; negative regulation of alkaline phosphatase activity; negative regulation of macrophage cytokine production; positive regulation of cell adhesion mediated by integrin; cell population proliferation; transforming growth factor beta receptor signaling pathway; negative regulation of cell population proliferation; positive regulation of stress-activated MAPK cascade; cell-cell junction organization; extrinsic apoptotic signaling pathway; collagen fibril organization; positive regulation of epithelial cell migration; neutrophil chemotaxis; positive regulation of cell growth; response to wounding; negative regulation of cell growth; positive regulation of cardioblast differentiation; glial cell migration; wound healing; positive regulation of ossification; cardiac muscle cell proliferation; positive regulation of epithelial to mesenchymal transition; odontogenesis; positive regulation of timing of catagen; positive regulation of immune response; regulation of complement-dependent cytotoxicity; positive regulation of protein secretion; epithelial to mesenchymal transition; embryonic digestive tract development; response to hypoxia; cell-cell signaling; positive regulation of pathway-restricted SMAD protein phosphorylation; heart morphogenesis; platelet degranulation; salivary gland morphogenesis; generation of neurons; negative regulation of immune response; cell morphogenesis; positive regulation of cell population proliferation; positive regulation of phosphatidylinositol 3-kinase signaling; cell migration; activation of protein kinase activity; positive regulation of cell division; cardiac epithelial to mesenchymal transition; BMP signaling pathway; cell development; skeletal system development; kidney development; neural tube closure; hair follicle development; outflow tract septum morphogenesis; membranous septum morphogenesis; heart valve morphogenesis; atrioventricular valve morphogenesis; pulmonary valve morphogenesis; endocardial cushion morphogenesis; cardiac right ventricle morphogenesis; ventricular trabecula myocardium morphogenesis; endocardial cushion fusion; atrial septum primum morphogenesis; neural retina development; heart development; male gonad development; hemopoiesis; embryonic limb morphogenesis; hair follicle morphogenesis; ascending aorta morphogenesis; dopamine biosynthetic process; positive regulation of cell cycle; negative regulation of Ras protein signal transduction; somatic stem cell division; neuron development; inner ear development; uterus development; pathway-restricted SMAD protein phosphorylation; ventricular septum morphogenesis; atrial septum morphogenesis; pharyngeal arch artery morphogenesis; regulation of apoptotic process involved in outflow tract morphogenesis; substantia propria of cornea development; cranial skeletal system development; negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; regulation of signaling receptor activity; negative regulation of gene expression; negative regulation of angiogenesis; positive regulation of Notch signaling pathway; SMAD protein signal transduction; positive regulation of pri-miRNA transcription by RNA polymerase II; embryo development ending in birth or egg hatching; regulation of timing of catagen; secondary palate development; regulation of cell population proliferation; regulation of apoptotic process; regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	7042
	21808
	ENSG00000092969
	ENSMUSG00000039239
	P61812
	P27090
	NM_003238; NM_001135599
	NM_009367; NM_001329107
	NP_001129071; NP_003229
	NP_001316036; NP_033393
	Wikidata
View/Edit Human	View/Edit Mouse

Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin). It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. There are two named isoforms of this protein, created by alternative splicing of the same gene (i.e., TGFB2).

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